Skip to main content
. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Free Radic Biol Med. 2008 Sep 23;45(12):1653–1662. doi: 10.1016/j.freeradbiomed.2008.09.011

Figure 4. Short-term activation of CFTR Cl- transport and corresponding cytosolic redox potential changes by pyocyanin.

Figure 4

(A,B) Stimulation of Cl- currents (ΔICl) and intracellular redox potentials (Eredox) by 100 μM pyocyanin or 10 μM H2O2 in CFTR-corrected CFBE41o- monolayers plotted at 0, 1, 2, 3 and 4 minutes. Note that pyocyanin-induced ΔICl and ERedox were similar to those elicited by 10 μM H2O2. (C) Relationship between ΔICl and Eredox; line is regression line with slope = 1.41±0.05 μA·cm-2·mV-1, offset = 446±13.6 μA/cm2; dotted line is 95% confidence interval. Legend in panel A applies to all panels.