Table 1.

Sensitivity and specificity of ANA and its clinically important subtypes [18,19]

Autoantibodies	Associated CTD	Sensitivity	Specificity
ANA	SLE	93	57
	Sjogren's syndrome	48	52
	SS	85	54
	PM/dermatomyositis	61	63
	Raynaud phenomena	64	41
Specific ANA
Anti-dsDNA	SLE	57	97
Anti-Sm	SLE	25–30	High*
Anti-SSA/Ro	Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome	8–70	87
Anti-SSB/La	Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome	16–40	94
Anti-U3-RNP	SS	12	96
Anticentromere	Limited cutaneous SS	65	99.9
Scl-70	SS	20	100
Jo-1	PM	30	95

* Precise data not available.