Table 1.
Standardized mean differences (SMD) for changes from baseline in the three treatment arms separately.
| No. of patients | No. of treatment arms | SMD (95% confidence interval) | I2 (%) | |
|---|---|---|---|---|
| No treatment Overall | 978 | 37 | -0.24 (-0.36 to -0.12) | 25 |
| Depression | 42 | 3 | -0.44 (-1.27 to 0.39) | 70 |
| Nausea | 60 | 2 | -0.63 (-0.97 to -0.30) | 0 |
| Pain – acute | 63 | 5 | -0.53 (-1.03 to -0.02) | 49 |
| Pain – chronic | 265 | 11 | -0.10 (-0.27 to 0.06) | 0 |
| Phobia | 28 | 3 | -0.39 (-0.91 to 0.12) | 3 |
| Smoking | 391 | 2 | -0.40 (-0.54 to 0.26) | 0 |
| Obesity | 46 | 5 | -0.02 (-0.41 to 0.36) | 0 |
| Insomnia | 83 | 6 | 0.03 (-0.27 to 0.33) | 0 |
| Placebo Overall | 849 | 37 | -0.44 (-0.61 to -0.28) | 57 |
| Depression | 44 | 3 | -0.54 (-1.53 to 0.44) | 80 |
| Nausea | 59 | 2 | -1.02 (-1.37 to -0.66) | 0 |
| Pain – acute | 62 | 5 | -0.48 (-1.03 to 0.07) | 57 |
| Pain – chronic | 241 | 11 | -0.32 (-0.59 to -0.04) | 54 |
| Phobia | 32 | 3 | -0.85 (-1.35 to -0.36) | 0 |
| Smoking | 272 | 2 | -0.58 (-1.37 to 0.22) | 78 |
| Obesity | 58 | 5 | -0.17 (-0.52 to 0.18) | 0 |
| Insomnia | 81 | 6 | -0.31 (-0.61 to 0.00) | 0 |
| Active treatment Overall | 1073 | 52 | -1.01 (-1.16 to -0.86) | 57 |
| Depression | 49 | 3 | -1.27 (-1.91 to -0.62) | 53 |
| Nausea | 60 | 2 | -1.39 (-2.58 to -0.23) | 87 |
| Pain – acute | 61 | 5 | -2.12 (-3.01 to -1.24) | 73 |
| Pain – chronic | 373 | 17 | -0.81 (-1.03 to -0.59) | 52 |
| Phobia | 48 | 5 | -1.15 (-1.67 to -0.63) | 33 |
| Smoking | 275 | 3 | -0.99 (-1.16 to -0.81) | 0 |
| Obesity | 61 | 5 | -0.53 (-1.23 to 0.17) | 73 |
| Insomnia | 146 | 12 | -1.06 (-1.30 to -0.82) | 0 |