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Graphical representation of the significant Time by baseline WMH by baseline atrophy interaction. For the purpose of graphical presentation, WMH severity (circles and triangles) and degree of atrophy (upper and lower panel) are displayed in high and low groups based on the median severity. Note that the predicted mMMS scores decline most precipitously among individuals with greater level of atrophy and the greater baseline WMH burden (lower panel, circles).
