FIGURE 4.

Stereo diagrams of the homology model of S. pombe profilin bound to actin based on the bovine profilin-β actin crystal structure (PDB 1HLU). Color code for C-α traces: actin, dark blue; bovine profilin, cyan; S. pombe profilin, tan. ATP is yellow. Some residues discussed in the text are shown in stick representation. Subdomains 1–4 of actin are labeled in panel A. Important secondary structural elements are also labeled. The figure in panel B is oriented to highlight the β4/β5 and β5/β6 wings in bovine profilin. The figure was generated using Molscript and Raster3D.