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. 2008 Dec 24;106(1):256–261. doi: 10.1073/pnas.0803343106

Fig. 3.

Fig. 3.

IL-4 and Il-13 are required for proper biopsy wound healing. (A) Plots of mRNA expression (mean ± SD) for Th1 and Th2 cytokines in biopsy injured WT and Trem2−/− mice. For each mouse genotype, comparisons between individual time points post injury were compared with uninjured areas (0 h). Statistically significant differences (P < 0.01) are denoted by either blue asterisks (WT) or red asterisks (Trem2−/−). (B and C) Administration of neutralizing antibodies for TNF-α and IFN-γ accelerated the healing in Trem2−/− mice. Administration of neutralizing antibodies for IL-4 and IL-13 delayed wound healing in WT mice. For both experiments, the healing curves were statistically different (P < 0.001) as determined by generalized estimating equations, n = 12 lesions from 3 mice per group (see Table S1 for description and p values). (D) Plots of mean (± SD) fold-change of relative mRNA expression as determined by qRT-PCR analysis of wound beds procured at day 2 post injury (baseline of expression is 0h for each genotype) for WT, Myd88−/−, Trem2−/− mice (n = 12 lesions/group from 3 mice per group). Statistically significant differences (P < 0.01) as determined by Student's t tests between groups are indicated by an orange asterisk.