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. 2008 Dec 30;106(1):316–321. doi: 10.1073/pnas.0806518106

Fig. 3.

Fig. 3.

Arc/Arg-3.1 SARE replicates Arc7000 promoter activity. (A) Comparison across multiple mammalian species. Conserved sequences were highlighted in gray. A short stretch of sequences (thick line) consisted of 4 highly conserved boxes (boxes A–D) was termed a synaptic activity responsive element (SARE). (B) Dendrogram showing the divergence of SARE sequences across various mammalian species. The numbers represent the branch length, which indicates the degree of nucleotide differences. Detailed nucleotide information for this analysis is shown in Fig. S3. (C) SARE-ArcMin reporter vector. SARE was fused directly upstream of ArcMin, a TATA-containing sequence around the transcription initiation site of the Arc/Arg-3.1 gene. (D) SARE-ArcMin replicates the activation ability of Arc7000. n = 5 independent experiments. ***, P < 0.001; ns, not significant, compared with the TTX or the 4AP/BIC value of ArcMin (1-way ANOVA with Tukey's test).