Figure 6.

(A) Western blots for Bcl-2 expression following siRNA infection. Note that Bcl-2 protein expression is inhibited following infection with Bcl-2 siRNA at baseline and after treatment with 400 J/m². (B) Results of UV-B irradiation and Bcl-2 siRNA on apoptosis as determined by Annexin V staining; siRNA against lamin A/C served as a control. Note that inhibition of Bcl-2 causes a small, but statistically significant increase in apoptosis in response to low dose UV-B irradiation. The bar graphs depict the mean + SEM of at least 3 individual experiments. (&, p<0.01 compared to non-irradiated corresponding control; *, p<0.001 compared to non-irradiated corresponding controls)