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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Cancer Res. 2009 Jan 15;69(2):440–448. doi: 10.1158/0008-5472.CAN-08-1892

Figure 5. p18Ink4c preserves cell cycle arrest and blocks PNET progression in Irbp-Cyclin D1 mice.

Figure 5

(A and B) Western blotting reveals the indicated proteins in pineal gland lysates from mice of the indicated genotypes at P10 and 2 months. HA denotes hemagglutinin epitope on the human Cyclin D1. (C) Immunohistochemical staining for the proliferation marker Ki67 (top two panels) and heterochromatin-associated H3-K9M (bottom panel) in the pineal gland of the indicated mice at P49. (D) Representative photomicrographs showing Irbp-Cyclin D1, Ink4c -/- pineal gland tumor in whole mount (a) and following H&E staining (b).