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. 2009 Jan 21;106(5):1457–1461. doi: 10.1073/pnas.0809339106

Fig. 4.

Fig. 4.

Synergistic premature adult lethality of dapk-1 with immunocompromised mutants. (A) dapk-1 double mutants with tir-1 or mapk mutants die within 48 h of L4 stage (n > 200, for each genotype); dapk-1; pmk-1 premature lethality is partly suppressed by growth on ampicillin, carbenicillin (data not shown), or FUDR (n > 50, for each). Comparisons use Fisher exact test. (B) dapk-1 lifespan is not significantly different from the wild type (median 12 days unwounded, 7 days wounded). (C) Synergism of dapk-1 and tir-1: dapk-1; tir-1 (median 3 days) is significantly different from tir-1 (median 8 days) (P < 0.001). (D) The lifespan of pmk-1 is reduced 4-fold by wounding (P < 0.001); wounding on FUDR reduces pmk-1 lifespan by only 1.25-fold (P = 0.06 between pmk-1 wounded and unwounded on FUDR). (E) The synergistic reduction in lifespan of dapk-1; tir-1 double mutants is suppressed by FUDR; lifespan of dapk-1 tir-1 FUDR+ is not different from dapk-1 alone (P = 0.9).