Table 2.

Results of Association Studies of Single-Nucleotide Polymorphisms (SNPs) in the CHI3L1 Gene and Its Upstream Region on Chromosome 1q32.1 among the Hutterites.^*

SNP	Location Relative to Translational Start Site	Distance from p Terminus	Minor-Allele Frequency	P Values for Association
				Serum YKL-40 Level	Percent of Predicted FEV1	Percent of Predicted FVC	FEV1:FVC	FEF25–75	Total Serum IgE	Asthma	Bronchial Hyperresponsiveness	Atopy
	base pairs
rs871799	−14,120	201,436,494	0.18	0.03	0.29	0.23	0.99	0.83	0.68	0.86	0.68	0.93
rs2153101	−12723	201,435,097	0.21	9.7×10−13	0.02	0.10	6.7×10−4	0.03	0.40	0.008	5.9×10−4	0.24
rs946263	−9630	201,432,004	0.21	9.7×10−13	0.02	0.10	6.7×10−4	0.03	0.40	0.008	5.9×10−4	0.24
rs4950929	−4375	201,426,749	0.21	1.3×10−12	0.02	0.11	7.3×10−4	0.03	0.39	0.008	5.9×10−4	0.23
rs6691378	−1371	201,423,745	0.21	3.8×10−5	0.03	0.02	0.59	0.59	0.68	0.82	0.46	0.54
rs10399805 (tag SNP)	−247	201,422,621	0.24	5.8×10−5	0.10	0.05	0.30	0.74	0.94	0.83	0.68	0.97
rs4950928 (tag SNP)	−131	201,422,505	0.22	1.1×10−13	0.046	0.50	0.002	0.03	0.37	0.047	0.002	0.20
rs1538372 (tag SNP)	+1220 (intron 2)	201,421,155	0.38	3.1×10−3	0.89	0.67	0.05	0.37	0.69	0.33	0.43	0.92
rs880633 (tag SNP)†	+2951 (exon 5)	201,419,424	0.41	0.67	0.27	0.79	0.20	0.45	0.07	0.33	0.16	0.78
rs2275352 (tag SNP)	+5573 (intron 7)	201,416,802	0.24	1.8×10−4	0.11	0.047	0.58	0.97	0.57	0.49	0.24	0.53

^*Associations were evaluated with use of the general two-allele model test for quantitative phenotypes¹⁶ and the case–control quasi-likelihood test¹⁷ for binary phenotypes. Allele frequencies are corrected for relatedness.²¹ Distances are based on build 126 of the National Center for Biotechnology Information’s SNP database (dbSNP). FEF_25–75 denotes forced expiratory flow between 25% and 75% of the forced vital capacity (FVC), and FEV₁ forced expiratory volume in 1 second.

^†This SNP is the validated nonsynonymous SNP Arg145→Gly.