Table 1.
Plasma oxylipins by regioisomer (nM)a
| Oxylipin | Normolipidemic | Hyperlipidemic | p-value | Fold Difference |
|---|---|---|---|---|
|
Mid-chain Alcohols | ||||
| 9-HODE | 581 (320, 840) | 1170 (780, 1600) | 0.03 | 2.0 |
| 13-HODE | 627 (300, 950) | 1270 (1000, 1500) | 0.03 | 2.0 |
| 5-HETE | 2660 (1900, 3400) | 4630 (3500, 5800) | 0.03 | 1.7 |
| 8-HETE | 808 (390, 1200) | 1440 (840, 2000) | 0.03 | 1.8 |
| 9-HETE | 1570 (800, 2300) | 2570 (1500, 3600) | 0.06 | -- |
| 11-HETE | 956 (500, 1400) | 1610 (1000, 2200) | 0.03 | 1.7 |
| 12-HETE | 1690 (830, 2600) | 2880 (2400, 3400) | 0.03 | 1.7 |
| 15-HETE | 1510 (720, 2300) | 2880 (2200, 3600) | 0.03 | 1.9 |
| 15-HETrE | 30 (20, 40) | 126 (74, 180) | 0.03 | 4.2 |
|
| ||||
|
Ketones | ||||
| 9-oxo-ODE | 133 (87, 180) | 265 (210, 320) | 0.03 | 2.0 |
| 13-oxo-ODE | 161 (120, 210) | 461 (340, 580) | 0.03 | 2.9 |
| 5-oxo-ETE | 244 (190, 290) | 607 (210, 1000) | 0.03 | 2.5 |
| 15-oxo-ETE | 89.3 (56, 120) | 303 (140, 470) | 0.03 | 3.4 |
|
| ||||
|
Epoxides | ||||
| 9(10)-EpOME | 27.2 (16, 38) | 47.4 (15, 80) | 0.2 | -- |
| 12(13)-EpOME | 34.3 (21, 47) | 76.3 (53, 100) | 0.03 | 2.2 |
| 5(6)-EET | 144 (67, 220) | 340 (120, 560) | 0.03 | 2.4 |
| 8(9)-EET | 89.3 (44, 130) | 205 (86, 320) | 0.03 | 2.3 |
| 11(12)-EET | 48.5 (28, 69) | 87.1 (33, 140) | 0.1 | -- |
| 14(15)-EET | 50.1 (21, 79) | 98.9 (19, 180) | 0.1 | -- |
|
| ||||
|
Diols | ||||
| 9,10-DHOME | 24.8 (9.3, 40) | 63.9 (13, 120) | 0.06 | -- |
| 12,13-DHOME | 35.8 (18, 53) | 114 (7.7, 220) | 0.03 | 3.2 |
| 5,6-DHET | 35 (27, 43) | 46.8 (28, 66) | 0.2 | -- |
| 8,9-DHET | -- | -- | -- | -- |
| 11,12-DHET | 26 (−42, 94) | 7.42 (3.7, 11) | 0.5 | -- |
| 14,15-DHET | 32.4 (−52, 120) | 10.4 (4.3, 17) | 0.5 | -- |
|
| ||||
|
ω ω-1 Alcohols | ||||
| 19-HETE | 27.7 (17, 39) | 35.5 (17, 54) | 0.2 | -- |
| 20-HETE | 27.9 (7.2, 49) | 34.4 (16, 53) | 0.5 | -- |
|
| ||||
|
Triols | ||||
| 9,10,13-TriHOME | 5.32 (1.7, 9) | 8.16 (−0.36, 17) | 0.5 | -- |
| 9,12,13-TriHOME | 25.5 (11, 40) | 40.8 (3.8, 78) | 0.7 | -- |
| 11,12,15-THETrE | 213 (110, 320) | 270 (140, 400) | 0.3 | -- |
a
All results are shown as the least-squares mean (95% CI).
b
Significance of 2-tailed t-Tests were evaluated after false discovery rate adjustments with a q = 0.1 (*), and 0.05(**) by the methods of Benjamini and Hochberg [8]. Dashed lines (--) indicate insignificant changes.