Table 4.

Details About Treatment and Outcome for all Patients

Patient Number	Dosage Level(mg/m2)	Age at Diagnosis/Gender	Histologic Diagnosis	Tumor Location	Surgical Resection	PFS (years)
1	70	7.5/M	Anaplastic Astrocytoma	Cerebellum	Biopsy	0.7
2	70	10/M	Glioblastoma	Multifocal	PR	2.2
3	70	8.2/F	Glioblastoma	Thalamus	STR	0.5
4	70	6.3/F	Glioblastoma	Thalamus	NTR	0.7
5	70	9.9/F	Glioblastoma	Gliomatosis Cerebri	PR	0.9
6	70	10.4/F	Anaplastic Astrocytoma	Gliomatosis Cerebri	Biopsy	1.9
7	70	14/M	Glioblastoma	Temporal Lobe	NTR	1.3
8	90	22.5/M	Anaplastic Oligoastrocytoma	Temporal Lobe	GTR	1.9
9	90	11.8/M	Anaplastic Ganglioglioma	Frontal Lobe	GTR	2.2 +
10	90	18.1/F	Anaplastic Astrocytoma	Temporal Lobe	GTR	2.2 +
11	120	13.1/M	Glioblastoma	Temporal Lobe	GTR	2.1 +
12	120	14.4/F	Glioblastoma	Frontal Lobe	NTR	0.6
13	120	3.7/F	Glioblastoma	Frontal Lobe	NTR	0.2
14	120	7.2/M	Glioblastoma	Bi-thalamic	Biopsy	0.4
15	120	13.7/M	Glioblastoma	Frontal Lobe	STR	0.4
16	120	6.2/M	Anaplastic Oligoastrocytoma	Parietal Lobe	GTR	1.5 +
17	120	19/M	Anaplastic Astrocytoma	Frontal Lobe	STR	1.5 +
18	160	13.2/F	Anaplastic Astrocytoma	Brainstem	NTR	1.3 +
19	160	14.8/M	Glioblastoma	Frontal Lobe	NTR	0.6
20	160	10.7/F	Glioblastoma	Thalamus	STR	0.2
21	160	8/F	Anaplastic Astrocytoma ‡	Thalamus	Biopsy	1.2
22	160	14.3/M	Anaplastic Astrocytoma	Frontal Lobe	STR	1 +
23	160	7.4/M	Anaplastic Astrocytoma ‡	Cerebellum	STR	0.9

Abbreviations: PFS, progression-free survival; PR, partial resection; STR, subtotal resection; NTR, near-total resection; GTR, gross total resection

^‡Histologic diagnosis was changed to glioblastoma at second operation