Diabetes recurred more slowly in diabetic NOD-RIP-CD80 mice. A, Transplant survival was monitored in diabetic NOD, NOD-RIP-CD80, and NOD-RIP-CD86 mice in which islets from 6-wk-old NOD mice were transplanted under the kidney capsule and rendered euglycemic after 48 h. The difference in time of development of recurrent diabetes was statistically significant (p < 0.05). B, Cellular phenotypes infiltrating transplanted islets in diabetic NOD (Tg negative (−ve)), NOD-RIP-CD80, and NOD-RIP-CD86 were examined by immunohistochemistry on frozen sections.