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. 2009 Feb 3;4(2):e4309. doi: 10.1371/journal.pone.0004309

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Slominski et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Fragments of rat adrenal glands were incubated with 7DHP (0.5 mM) in the absence (pink) or presence (gray) of trilostane (0.1 mM) and samples analyzed by RP-HPLC. Boiled adrenal fragments (green) or incubations without the substrate (blue) were used as negative controls. B. The relative concentrations of the identified products affected by trilostane (T). The insert shows inhibition of 7DHP consumption by trilostane. Control marked by blue represents or incubations without the substrate.