Table 1.
Substrates/cofactors | Km (mM) | Vmax (nmol/min/mg) | Kcat (/min) | Kcat/Km (min/mM) |
---|---|---|---|---|
Kynurenine | 0.89 ± 0.07 | 3550 ± 87 | 113 ± 2.8 | 127 ± 12 |
NADPH | 0.82 ± 0.10 | 3821 ± 188 | 122 ± 6.0 | 149 ± 26 |
NADH | 5.17 ± 0.97 | 1616 ± 110 | 51 ± 3.5 | 10 ± 2.6 |
The biochemical activities were measured as described in the Experimental procedures. The kinetic parameters of rAeKMO were calculated by fitting the experimental data to the Michaelis–Menten equation using the Enzyme Kinetics Module (SPSS Science).