TABLE 4.
Confirmation of Array Results Based on Expected Gene Expression in Effector CTL (CD8+CD57+)
| Gene symbol | Gene name | Function | Fold change CD57+ versus CD57− |
|---|---|---|---|
| B3GAT1 | β-1,3-Glucuronyltransferase (CD57 transferase) | Cell adhesion | 56 |
| GZMB | Granzyme B | Proteolysis | 4.6 |
| CD38 | CD38 antigen (p45) | Cell death regulation | 5 |
| HLA-DQ | MHC class II | Cell adhesion/antigen processing | 3.5 |
| HLA-DR | MHC class II | Cell adhesion/antigen processing | 5.2 |
| PRSS23 | Serine protease 23 | Effector cells, antiviral | 8.4 |
| TNFRS7 (CD27) | TNFRSF | Lymphocyte homeostasis | −2.2 |
| CD28 | CD28 antigen (Tp44) | Cell death regulation | −11.3 |
| IL7R(CD127) | IL-7R | Signal transduction | −2.2 |
| BCL2 | B cell lymphoma 2 | Cell death regulation | −2.8 |
| CCR7 | Chemokine receptor 7 | Homing marker | −2.8 |