Table 1.
Amphetamine-induced changes in rCBV in both naive and MPTP-treated animals
|
Structure |
rCBV change naive |
rCBV change after MPTP |
Percentage change |
p value |
|---|---|---|---|---|
| Occipital Cx | −8.0 ± 2.8 | −11.9 ± 5.7 | NS | |
| Motor Cx | 0.1 ± 5.9 | −4.6 ± 7.5 | NS | |
| Superior temporal gyrus | 19.0 ± 4.9 | 18.3 ± 9.6 | NS | |
| Cingulate Cx | 14.4 ± 4.9 | 7.4 ± 6.1 | −48.5 | <0.01 |
| Precentral gyrus | 21.6 ± 8.4 | 2.5 ± 7.3 | −88.3 | <10−3 |
| Insular Cx | 7.7 ± 7.4 | 0.0 ± 6.1 | −99.9 | <0.05 |
| Globus pallidus | −7.0 ± 2.9 | −7.7 ± 5.4 | NS | |
| Nucleus accumbens | 19.1 ± 4.9 | 12.1 ± 7.2 | −36.9 | <0.05 |
| Parafascicular thalamus | 29.6 ± 6.7 | 14.6 ± 15.0 | −50.5 | <0.05 |
| Putamen | 25.2 ± 2.9 | 3.5 ± 10.2 | −86.1 | <10−3 |
| Caudate | 23.6 ± 6.4 | 2.2 ± 5.2 | −90.8 | <10−5 |
| Red nucleus | 21.6 ± 8.3 | −1.3 ± 9.4 | −106.0 | <10−3 |
| VTA | 30.9 ± 16.7 | 0.1 ± 8.2 | −99.8 | <0.01 |
| Substantia nigra | 28.7 ± 7.6 | −3.5 ± 5.6 | −112.4 | <10−6 |
| Dentate nucleus cerebellum |
9.5 ± 3.2 |
−0.9 ± 8.1 |
−108.9 |
<0.05 |
Changes in rCBV are reported for the average over 30 min after amphetamine administration. These data represent animals studied at 2.5 mg/kg amphetamine. Ten animals were treated with MPTP. One was excluded from this table because the animal was scanned with 1.5 mg/kg amphetamine. The other animal excluded from the table was the animal with only a partial lesion and no symptoms. Cx, Cortex; VTA, ventral tegmental area.