Table 2.
Information on biological processes based on Gene ontology.
| Biological Process | Up-regulated genes |
| Cell communication | |
| signal transduction | ARHGAP29, BST2, CCL2, CXCL14, CMIP, FLNB, GNAI2, LY6E |
| cell-cell signaling | BST2, CCL2 |
| Transcription | MZF1, NRG1, RP13-122B23.3, ZNF452 |
| Translation | RPS15, RPS23 |
| Apoptosis | INCA |
| induction | BID |
| anti-apoptosis | ANGPTL4, CCL2, IFI6, XAF1 |
| Cell adhesion | AJAP1, CCL2, MSLN, SAA1 |
| Cell migration | MYH9, SAA1, LUM |
| Cell cycle | PLK1 |
| Cell division | MYH9 |
| Cell proliferation | BOLA2, BST2, PLK1 |
| Cellular development process | |
| cell differentiation | MYH9 |
| keratinocyte differentiation | S100A7, SPRR2F |
| Cellular structure morphogenesis | MYH9 |
| Developmental process | BST2, SPRR2F |
| organ development | CCL2, MEPE, SPARC |
| epidermis development | COL1A1, COL7A1, KRT14, LAMC2, S100A7, SPRR2F |
| keratinization | SPRR2F |
| Response to stimulus | |
| defense response | |
| inflammatory response | IL1F5, SERPINA3 |
| immune response | BST2, CCL2, IFI6, IFITM2, IL1F5, SEMA3C |
| response to stress | DTL, SGK |
| response to oxidative stress | S100A7 |
| response to external stimulus | CXCL14, CCL2, GNAI2, S100A7, SAA1, SEMA3C, TOPBP |
| Angiogenesis | ANGPTL4, MYH9 |
| Transport | MYH9, NEFL, RBP1, SGK, SLC15A3, SLC6A8 |
| Metabolic process | NADK |
| protein metabolic process | INCA, LEPREL1, MYH9, NRG1, PRSS21, PSMC1 |
| protein modification process | CCL2, DTL, FKBP9L, HSPE1, ISG15, SGK, TOR3A |
| lipid metabolic process | APOC1, APOL1, CEL, PLA2G4E, PTGS1, SERPINA3 |
| carbohydrate metabolic process | NANS |
| DNA metabolic process | DTL, H3F3B |
| nucleic acid metabolic process | 0ERH |
| RNA processing | LSM4, SNRPD3 |
| Cytoskeleton organization | FLNB, MYH9, NEFL, PLEK2 |
| Extracellular structure organization | LUM |
| Viral genome replication | CCL2 |
| Cellular homeostasis | CCL2, IFI6, SAA1, SELT |
| No classification | BASP1, CCNYL1, F8A1, FGFBP2, GRAMD1B, IFI27, KIAA1467, KIAA1799, KRTDAP, MFAP2, MSMB, NOL6, OLFML2A, SNCG |
| Down-regulated genes | |
| Cell communication | |
| signal transduction | ANXA1, ARHGAP27, CD24, CRABP2, DBNL, ECM1, GPR126, IL6R, MAL, TNFSF10, TSPAN6, TYRO3 |
| cell-cell signaling | CD24, MAL, S100A9, TNFSF10 |
| Transcription | CRABP2, EHF, HOP, PTRF |
| Apoptosis | |
| induction | CLU, MAL, TNFSF10 |
| anti-apoptosis | ANXA1, SERPINB2 |
| Cell adhesion | CLDN4, TYRO3 |
| Cell migration | ANXA1, CD24, PRSS3 |
| Cell proliferation | IL6R, EHF |
| positive regulation | CLU, TSPAN31, CD24 |
| Cellular development process | |
| cell differentiation | CLU, HOP, KRT19, MAL |
| keratinocyte differentiation | A2ML1, ANXA1, SPRR3, TGM3 |
| epithelial cell differentiation | EHF |
| Developmental process | EHF, IL6R, MAL |
| organ development | CLU, HOP, MAL |
| ectoderm development | KRT6A |
| epidermis development | CRABP2, KRT13, SPRR3, TGM3 |
| epidermal cell differentiation | |
| keratinization | CNFN, PPL, SPRR3 |
| Response to stimulus | |
| defense response | NCF1 |
| inflammatory response | ANXA1, LYZ, MGLL, S100A8, S100A9 |
| immune response | CLU, CR1, GBP6, IL1RN, IL6R |
| response to stress | CD24, CLU |
| response to external stimulus | CAT, CD24, CSTB, KRT8, PDE6B, SPRR3 |
| Transport | ALDH3A1, AQP5, ARHGAP27, CAT, CD24, KIF1C, PGD, PLLP, RHCG, SPNS2 |
| Metabolic process | ALDH3A1, CD24, ECHDC3, TPI1 |
| protein metabolic process | PRSS3, RANBP9, TMPRSS11E, UBR4, USP10 |
| protein modification process | ANXA1, PRSS3, TGM3, USP10 |
| lipid metabolic process | AKR1C2, ANXA1, APOD, CLU, LTB4DH, MGLL, PIGF, TPI1 |
| carbohydrate metabolic process | PGD, TPI1 |
| Lymphocyte activation | CD24 |
| Homeostasis | RHCG, CD24 |
| No classification | C20orf149, C6orf205, C9orf58, CAPNS2, CRCT1, DIS3L2, FAM129B, GPRASP2, HPCAL1, IER2, IGHA1, KRT78, LOC342897, LOC643008, LYPD2, LYPD3, MGC59937, MUC1, NUCKS1, PRH1, TMEM59, TPPP3, ZFAND1 |
Top up- and down-regulated genes selected from SAGE in tumor samples compared to normal samples.