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. 2008 Dec 25;8:390. doi: 10.1186/1471-2407-8-390

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Copyright © 2008 Dotan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cells of a healthy (cancer free) individual (case K2) heterozygous for the large CEN15 marker (derived from the paternal parent) after two-color FISH with SNRPN (red signals) and CEN15 (green signals). Left, two interphase cells representing SD cells for SNRPN and SS cells for CEN15. Right, cell at metaphase with chromosome-15 homologues identified by the CEN15 and SNRPN signals. Note the difference in signal size between the two CEN15 counterparts in each cell, and the association of the replicated SNRPN locus (doublet; D-signal) in both interphase cells with the large CEN15.