Table 1.

Demographics of Frontotemporal Dementia Patients

Demographics	Total	Tauopathy	FTLD-Ua	DLDH	AD	Other
Age at onset (range), yr	60.4 (30-82), n = 111b	61.0 (30-77), n = 51	60.3 (46-79), n = 33	54.8 (43-80), n = 4	60.3 (34-82), n = 19	59.8 (50-70), n = 4
Sex, M:F (% male)	58:56 (50.9%)	28:25 (53%)	14:19 (42%)	2:2 (50%)	10:9 (53%)	4:1 (80%)
Education (range), yr	15.3 (8-23), n = 85	15.3 (10-21), n = 36	15.2 (10-23), n = 25	16.0 (15-17), n = 3	15.8 (12-19), n = 18	12.0 (8-16), n = 3
Disease duration, (range), mo	89.1 (17-300), n = 109b	90.8 (24-300), n = 49	81.5 (20-264), n = 32	82.8 (36-120), n = 4	107.0 (24-204), n = 19	57.0 (17-151), n = 5
Family historyc	Probable: 17.0% Possible: 30.0%	Probable: 22.4% Possible: 22.4%	Probable: 19.2% Possible: 30.8%	Possible: 75.0%	Probable: 6.3% Possible: 43.8%	Possible: 20.0%

^aSix patients with frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) pathology were diagnosed clinically with motor neuron disease (MND) at some point after presentation. Mean age of onset = 51.3 years; mean education = 17.3 years; mean disease duration = 49.3 months.

^bInformation regarding age at onset of dementia was not available in three patients.

^cFamily history was coded according to the following criteria: definite = family history consistent with autosomal dominant pattern of inheritance (ie, at least three affected first-degree relatives in multiple generations) and/or identification of mutations in MAPT or valosin-containing protein genes; probable = two first-degree relatives with an FTLD diagnosis or related dementia; possible = one first-degree relative or two second-degree relatives with a diagnosis of FTLD or related dementia; none = no family history of FTLD or related condition. Information regarding family history was available in only 100 of the 114 patients.

DLDH = dementia lacking distinctive histopathology; AD = Alzheimer’s disease.