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. 2009 Feb 2;4(2):e4344. doi: 10.1371/journal.pone.0004344

Table 2. MRSA252 genes down-regulated following the addition of linoleic acid (0.1 mM) to exponentially growing cells (linoleic acid challenge).

Group Functions MRSA 252 ORF MRSA252 Gene MRSA252 Gene Product Fold Change Down Regulated P-value
Virulence Factors and Regulators SAR0105 plc 1-phosphatidylinositol phosphodiesterase 3.85 4.39E-04
SAR1574 fur iron uptake regulatory protein 2.08 2.46E-02
SAR1984 ferritin 2.56 4.39E-03
SAR2001 staphopain protease 2.44 3.00E-04
SAR2474 sarZ MarR family virulence regulator 2.22 2.18E-02
SAR2155 rsbU putative sigma factor sigB regulation protein 2.56 1.58E-03
SAR2715 argR arginine repressor family protein 2.27 4.27E-03
SAR2716 aur zinc metalloproteinase aureolysin precursor 2.17 1.76E-03
Energy Metabolism SAR0234 ldh1 L-lactate dehydrogenase 1 2.94 2.99E-05
SAR0235 putative PTS system, IIBC component 2.22 1.30E-03
SAR0242 putative galactitol PTS component 2.13 1.76E-02
SAR0263 putative PTS system protein 2.50 3.44E-02
SAR0355 Cys/Met metabolism PLP-dependent enzyme 2.04 2.74E-02
SAR0522 putative pyridoxal 5-phosphate biosynthesis protein 3.03 3.00E-04
SAR0523 SNO glutamine amidotransferase family protein 2.70 3.70E-04
SAR0752 putative phosphofructokinase 2.38 3.27E-02
SAR0753 fruA fructose-specific PTS system component 2.50 3.78E-02
SAR0766 glutamine amidotransferase class-I protein 2.04 6.16E-04
SAR1088 putative pyruvate carboxylase 2.5 8.78E-04
SAR1450 tdcB putative threonine dehydratase 2.22 5.47E-03
SAR1451 ald2 alanine dehydrogenase 2 3.03 1.15E-03
SAR1777 pfkA 6-phosphofructokinase 2.86 2.87E-03
SAR1789 ackA acetate kinase 2.33 9.23E-03
SAR2143 ilvC ketol-acid reductoisomerase 2.22 2.80E-02
SAR2213 fba putative tagatose-bisphosphate aldolase 3.13 6.59E-03
SAR2262 putative uridylyltransferase 2.27 8.35E-03
SAR2579 gtaB putative uridylyltransferase 2.63 6.84E-03
SAR2720 putative PTS system component 4.17 3.54E-03
SAR2721 pmi mannose-6-phosphate isomerase 3.57 2.76E-03
Cell Wall Synthesis SAR0228 putative glutamine amidotransferase class-I 2.13 2.08E-03
SAR0257 lytS autolysin sensor kinase protein 3.33 3.00E-03
SAR0258 lytR autolysin response regulator protein 3.57 9.15E-03
SAR0259 lrgA holin-like protein 2.22 1.20E-03
SAR0646 tagA teichoic acid biosynthesis protein 2.78 6.80E-03
SAR0648 tagG teichoic acid ABC transporter permease protein 2.38 1.32E-02
SAR0649 tagB teichoic acid biosynthesis protein 2.50 4.41E-04
SAR1143 putative carbamate kinase 2.27 6.79E-03
SAR1752 hemA glutamyl-tRNA reductase 2.27 3.93E-02
SAR1807 putative transglycosylase 2.04 8.78E-04
SAR2472 gltT putative proton/sodium-glutamate symport protein 2.04 2.97E-02
SAR2621 cidA holin-like protein 2.27 1.18E-02
SAR2669 putative dihydroorotate dehydrogenase 2.86 3.75E-03
Fatty Acid Metabolism SAR0225 fadD putative acyl-CoA dehydrogenase 2.17 3.27E-02
SAR0227 fadX putative acetyl-CoA transferase 2.13 4.95E-02
SAR0803 conserved hypothetical protein 3.23 1.02E-02
Carotenoid Biosynthesis SAR1278 miaA putative isopentenylpyrophosphate transferase 2.00 9.23E-03
SAR1479 putative heptaprenyl diphosphate synthase 2.78 1.62E-02
SAR1480 menH heptaprenylnaphthoquinone methyltransferase 2.27 3.54E-02
SAR1481 putative hexaprenyl diphosphate synthase 3.13 1.79E-02
DNA Repair and Replication SAR0001 dnaA chromosomal replication initiator protein DnaA 2.04 2.17E-03
SAR0004 recF DNA replication and repair protein RecF 2.08 8.51E-03
SAR0028 repB replication protein (pseudogene) 4.35 1.48E-02
SAR0485 holB putative DNA polymerase III, delta' subunit 3.03 1.26E-02
SAR0711 putative replication initiation protein 2.50 3.43E-02
SAR2429 putative 3-methylpurine glycosylase 2.22 1.87E-03
Metabolism SAR0246 ispD conserved hypothetical protein 2.00 2.27E-03
SAR0261 putative nitric oxide reductase 2.22 6.16E-04
SAR0302 putative formate/nitrite transporter 2.38 8.03E-03
SAR0524 nupC nucleoside permease 2.94 3.96E-03
SAR0562 putative deoxyadenosine kinase protein 2.17 2.64E-02
SAR0563 putative deaminase 2.50 3.75E-03
SAR0569 putative glycosyl transferase 2.13 4.40E-03
SAR0642 ABC transporter permease protein 2.56 9.65E-03
SAR0643 ABC transporter ATP-binding protein 3.70 9.25E-03
SAR0655 putative Na+ dependent nucleoside transporter 2.17 2.25E-03
SAR0743 putative sodium:sulfate symporter protein 2.22 4.39E-04
SAR0847 nuc thermonuclease precursor 3.33 3.70E-04
SAR0916 putative peptidyl-prolyl cis-trans isomerase 2.13 6.54E-03
SAR1008 putative glycosyl transferases 4.00 1.65E-03
SAR1014 acetyltransferase (GNAT) family protein 2.27 6.54E-03
SAR1090 ctaB putative protoheme IX farnesyltransferase 2.04 2.66E-02
SAR1185 putative guanylate kinase 2.78 6.16E-03
SAR1449 amino acid permease 2.50 2.65E-03
SAR1478 ndk putative nucleoside diphosphate kinase 2.38 3.03E-02
SAR1598 arginine repressor 2.50 3.23E-03
SAR1627 5-formyltetrahydrofolate cyclo-ligase family protein 2.78 2.27E-03
SAR1707 putative ATPase 2.13 1.36E-02
SAR1714 relA GTP pyrophosphokinase 2.27 3.96E-03
SAR1717 secF putative protein-export membrane protein 2.27 6.05E-03
SAR1804 putative acyltransferase 2.44 2.99E-02
SAR2129 scrR sucrose operon repressor 2.56 1.38E-02
SAR2130 ammonium transporter family protein 2.04 1.65E-03
SAR2340 acetyltransferase (GNAT) family protein 3.03 8.77E-04
SAR2363 modA putative molybdate-binding lipoprotein precursor 2.08 2.97E-02
SAR2432 CorA-like Mg2+ transporter protein 2.44 5.61E-03
SAR2493 putative formate/nitrite transporter 2.22 8.71E-03
SAR2594 ABC transporter ATP-binding protein 2.38 1.65E-03
SAR2789 putative subtilase family protease 2.04 2.27E-03
Hypothetical Genes SAR0013 putative membrane protein 2.17 1.81E-02
SAR0024 conserved hypothetical protein 3.03 2.27E-03
SAR0030 hypothetical protein 2.38 6.16E-03
SAR0048 putative membrane protein 2.08 1.08E-02
SAR0061 putative membrane protein 2.08 4.25E-02
SAR0063 hypothetical protein 2.56 1.02E-02
SAR0075 hypothetical protein 2.04 6.16E-04
SAR0078 hypothetical protein 2.08 9.65E-03
SAR0097 putative DNA-binding protein 2.17 2.99E-03
SAR0145 putative lipoprotein 2.13 1.56E-02
SAR0197 hypothetical protein 286 2.14E-02
SAR0216 putative lipoprotein 2.04 6.16E-04
SAR0338 putative membrane protein 2.86 2.40E-03
SAR0383 abortive infection bacteriophage resistance related 4.76 1.99E-02
SAR0618 putative iron compound-binding protein 2.27 4.08E-02
SAR0673 conserved hypothetical protein 2.70 4.55E-03
SAR0694 putative bacteriocin 2.38 3.75E-03
SAR0695 putative bacteriocin-immunity membrane protein 2.22 2.08E-03
SAR0718 putative membrane protein 3.33 9.93E-04
SAR0761 putative lipoprotein 2.86 3.00E-04
SAR0793 hypothetical protein 2.56 1.58E-02
SAR0846 secreted von Willebrand factor-binding homolog 2.17 1.94E-02
SAR0890 conserved hypothetical protein 2.56 8.06E-04
SAR0893 putative membrane protein 2.13 4.74E-02
SAR0898 conserved hypothetical protein 2.70 1.59E-02
SAR0899 conserved hypothetical protein 2.33 4.94E-03
SAR0915 kinase-associated protein B 2.44 8.06E-04
SAR0970 protozoan/cyanobacterial globin family protein 2.38 1.11E-02
SAR0971 conserved hypothetical protein 2.78 1.87E-03
SAR0979 putative membrane protein 2.50 2.25E-03
SAR0981 putative esterase 2.44 1.55E-03
SAR0982 putative restriction-modification system protein 2.44 1.37E-03
SAR0983 putative restriction-modification system protein 2.56 2.42E-03
SAR0985 putative 2′,5′ RNA ligase family 2.13 2.32E-02
SAR0987 putative monogalactosyldiacylglycerol synthase 2.56 6.54E-03
SAR1066 putative lipoprotein 2.50 4.74E-02
SAR1085 conserved hypothetical protein 2.33 3.44E-02
SAR1086 conserved hypothetical protein 3.45 6.54E-03
SAR1095 conserved hypothetical protein 2.86 2.16E-02
SAR1114 putative cell division protein ZapA 2.38 3.96E-03
SAR1148 putative DNA-binding protein 2.38 2.66E-02
SAR1154 MraZ protein 2.50 3.00E-03
SAR1312 hypothetical protein 3.85 3.27E-02
SAR1315 hypothetical protein 2.38 2.99E-03
SAR1316 hypothetical protein 2.27 1.79E-02
SAR1320 hypothetical protein 4.00 1.46E-02
SAR1335 putative exported protein 2.27 7.38E-03
SAR1389 conserved hypothetical protein (pseudogene) 2.33 5.63E-03
SAR1448 major facilitator superfamily transporter protein 2.04 4.57E-03
SAR1556 putative phage regulatory protein 2.08 5.64E-03
SAR1558 putative phage lipoprotein 2.44 1.24E-03
SAR1559 hypothetical phage protein 2.33 4.80E-04
SAR1560 hypothetical phage protein 2.04 1.72E-02
SAR1561 putative phage membrane protein 2.13 1.10E-03
SAR1581 conserved hypothetical protein 2.86 1.81E-02
SAR1592 conserved hypothetical protein 2.27 1.16E-02
SAR1699 conserved hypothetical protein 2.00 3.92E-03
SAR1706 putative transcriptional regulator 3.45 2.16E-02
SAR1708 conserved hypothetical protein 2.04 3.14E-03
SAR1770 putative membrane protein 2.13 2.99E-03
SAR1834 putative leucyl-tRNA synthetase 2.17 3.65E-02
SAR1885 hypothetical protein 2.63 6.97E-04
SAR1897 hypothetical protein 3.03 2.86E-02
SAR1935 probable phosphoesterase 2.78 2.37E-03
SAR1938 putative DNA-binding protein 2.38 2.80E-02
SAR2020 putative membrane protein 2.44 6.39E-03
SAR2035 putative exported protein 2.86 1.61E-02
SAR2113 hypothetical protein 2.86 4.64E-02
SAR2114 hypothetical protein 2.56 3.43E-02
SAR2115 hypothetical protein 2.86 4.22E-02
SAR2118 putative membrane protein 2.00 3.28E-03
SAR2119 membrane anchored protein 2.44 1.08E-03
SAR2156 pemK-like protein 3.03 5.61E-03
SAR2219 hypothetical protein 2.78 6.21E-03
SAR2261 putative membrane protein 2.08 6.02E-04
SAR2263 putative membrane protein 2.17 2.89E-03
SAR2299 hypothetical protein 2.04 3.47E-03
SAR2369 putative acyl-CoA dehydrogenase 2.86 1.94E-03
SAR2425 putative membrane protein 2.13 5.63E-03
SAR2428 putative membrane protein 2.00 3.23E-03
SAR2435 putative acyl hydrolase 2.50 3.02E-02
SAR2439 tetR family regulatory protein 2.22 3.23E-03
SAR2473 putative exported protein 3.85 3.97E-03
SAR2500 putative lipoprotein 2.86 8.48E-04
SAR2546 putative lipoprotein 3.13 2.76E-02
SAR2595 putative membrane protein 2.78 1.65E-03
SAR2718 putative exported protein 2.04 4.80E-04
SAR2719 transcriptional regulator 3.13 3.07E-04
SAR2792 putative membrane protein 3.85 2.78E-03
SAR2793 putative membrane protein 3.70 8.17E-04