. Author manuscript; available in PMC: 2009 Dec 25.

Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7944–7952. doi: 10.1021/jm800831y

Table 2.

bis(Diazeniumdioalate) Prodrugs 4a-5d

compd	R₂N substituent	R₂N substituent	precursors	yield (%)
4a	Me₂N–		3a, 2c	84
4b	Me₂N–		3a, 2d	95
4c	Me₂N–		3a, 2e	93
4d	Me₂N–		3a, 2f	94
4e	Me₂N–		3a, 2g	85
4f	Me₂N–		3a, 2h	90
4g	Me₂N–		3a, 2i	81
4h	Me₂N–		3a, 2j	79
4i	Me₂N–		3a, 2k	72
4j	Et₂N–	Me₂N–	3a, 2b	91
5a	Et₂N–		3b, 2c	77
5b			3c, 2f	81
5c	Et₂N–		3b, 2f	90
5d	Et₂N–		3b, 2k	87