Table 2.
Clinical trials on formoterol in COPD patients
| Author | Patients enrolled | Mean age (years) | Treatment |
|---|---|---|---|
| Cazzola et al 1994 | 16 | 64.3 | F 24 μg |
| SLM 50 μg | |||
| ALB 200 μg | |||
| PL | |||
| Cazzola et al 1995 | 12 | 62.5 | F 12 μg |
| F24 μg | |||
| SLM 50 μg | |||
| Vervloet et al 1998 | 482 | 48 | F 12 μg BID |
| SLM 50 μg BID | |||
| Celik et al 1999 | 22 | 57.3 | F 12 μg |
| SLM 50 μg | |||
| PL | |||
| Maesen et al 1999 | 12 | 61 | F 6 μg |
| F 24 μg | |||
| PL | |||
| Sichletidis et al 1999 | 27 | 64.7 | F 12 μg |
| F 24 μg | |||
| IPR 40 μg | |||
| IPR 80 μg | |||
| F 12 μg + IPR | |||
| 40 μg | |||
| PL | |||
| Benhamou et al 2001 | 24 | 61.6 ± 7.8 | F 24 μg |
| ALB 400 μg | |||
| PL | |||
| Cazzola et al 2001 | 16 | 65.6 | F 12 μg |
| F 24 μg | |||
| ALB 400 μg | |||
| ALB 800 μg | |||
| PL | |||
| Dahl et al 2001 | 780 | 63.7 | F 12 μg BID |
| F 24 μg BID | |||
| IPR 40 μg QID | |||
| PL | |||
| D’Urzo et al 2001 | 159 | 65 | F 12 μg |
| BID + IPR | |||
| 40 μg QID | |||
| SLM | |||
| 200 μg + IPR | |||
| 40 μg QID | |||
| Aalbers et al 2002 | 692 | 62.4 | F 4.5 μg BID |
| F 9 μg BID | |||
| F 18 μg BID | |||
| PL | |||
| Cazzola et al 2002 | 20 | 60.6 | F 9 μg |
| ALB 100 μg | |||
| F 18 μg | |||
| ALB 200 μg | |||
| Kottakis et al 2002 | 47 | 63.5 | F 12 μg |
| F 24 μg | |||
| SLM 50 μg | |||
| SLM 100 μg | |||
| PL | |||
| Rossi et al 2002 | 854 | 63 | F 12 μg BID |
| F 24 μg BID | |||
| THEO 200 mg | |||
| BID | |||
| THEO 300 mg | |||
| BID | |||
| PL | |||
| Di Marco et al 2003 | 20 | 65 | F 12 μg |
| ALB 200 μg | |||
| SLM 50 μg | |||
| OXITR 200 μg | |||
| PL | |||
| Bouros et al 2004 | 47 | 63.5 | F 12 μg |
| F 24 μg | |||
| SLM 50 μg | |||
| SLM 100 μg | |||
| PL | |||
| Cazzola et al 2004 | 20 | 70.7 | F 12 μg |
| TIO 18 μg | |||
| F 12 μg + TIO | |||
| 18 μg | |||
| Campbell et al 2005 | 657 | 60 | F 9 μg |
| BID + TER 0.5 | |||
| mg prn | |||
| F 9 μg BID + F | |||
| 4.5 μg prn | |||
| PL + TER | |||
| 0.5 mg prn | |||
| Di Marco et al 2006 | 21 | 72 | F 12 μg BID |
| TIO 18 μg QID | |||
| F 12 μg | |||
| BID + TIO | |||
| 18 μg QID |
Abbreviations: BID, twice daily; F, formoterol; IPR, ipratropium; OXITR, oxitropium, QID, 4 times daily; PL, placebo, SLM, salmeterol; TER, terbutaline; THEO, theophylline; TIO, tiotropium.