Figure 3.
Modulation of MRP1-mediated activity with increasing concentrations of (A) ipratropium bromide or (B) N-acetylcysteine. Dashed line indicates the MFI level of the control (incubation with vehicle). Data are shown of mean ± SEM of independent experiments for ipratropium bromide (n = 5 for 10−7 to 10−4 M; n = 1 for 2 × 10−4 M), and for N-acetylcysteine (n = 3–6 for 1 × 10−4 to 8 × 10−4 M; n = 1 for 1.6 × 10−3 M). *p < 0.05 compared with control.
Abbreviations: CF, carboxyfluorescein; MFI, mean fluorescence intensity; MRP1, multidrug resistance-associated protein 1.