Table 1.
GOLD classification, baseline pulmonary function, health-related quality of life, dyspnea score, exacerbation frequency, and hospitalization
| GOLD 2 | GOLD 3 | ||||
|---|---|---|---|---|---|
| Mean | SD | Mean | SD | p-value | |
| n (%); | 127 (71%) | 53 (29%) | |||
| n; male (%) ‡ | 88 (69 %) | 44 (83%) | n.s. | ||
| Age; yr ~ | 67 | ± 9 | 66 | ± 8 | n.s. |
| Current smoker; n (%) ‡ | 40 (31%) | 11 (21%) | n.s. | ||
| Never smoker; n ‡ | 8 (6%) | 2 (4%) | |||
| Pack years ^ | 38 | 37 | n.s. | ||
| FEV1 % pred ~ | 67 | ± 11 | 43 | ± 5 | p < 0.001 |
| ITGV % pred ~ | 128 | ± 27 | 150 | ± 28 | p < 0.001 |
| RV % pred ~ | 139 | ± 31 | 171 | ± 38 | p < 0.001 |
| DLco % pred ~ | 72 | ± 23 | 60 | ± 18 | p < 0.001 |
| SGRQ total ~ | 35.7 | ± 14.8 | 43.4 | ± 13.7 | 0.002 |
| SGRQ symptom ~ | 41.8 | ± 21.1 | 46.3 | ± 19.6 | n.s. |
| SGRQ activity ~ | 52.7 | ± 18.6 | 62.4 | ± 16.1 | 0.001 |
| SGRQ impact ~ | 23.9 | ± 15.1 | 31.2 | ± 16.1 | 0.004 |
| MRC ~ | 2.6 | ± 2.0 | 2.8 | ± 2.0 | n.s. |
| VAS dyspnea ~ | 69.4 | ± 13.9 | 68.5 | ± 14.8 | n.s. |
| Exacerbations ^ | 1 | 1.6 | 1.3 | 1.2 | 0.011 |
| Hospital admission ^ | 0.14 | 0.41 | 0.17 | 0.43 | n.s. |
Notes: Data are presented as mean ± SD unless otherwise indicated;
~
Independent Samples T-Test for continuous variables with normal distribution;
^
a nonparametric Mann Whitney U-Test;
‡
Chi-Squared Test for categorical variables.
Abbreviations: