. Author manuscript; available in PMC: 2009 Oct 7.

Published in final edited form as: J Theor Biol. 2008 Jul 4;254(3):674–690. doi: 10.1016/j.jtbi.2008.06.030

Table 1. Abbreviations and descriptions of the model variants used.

Abbreviation	Model Variant Description
NM	Nygren et al. model
NMf	Nygren et al. model with the following concentrations held constant: [K⁺]_i, [K⁺]_c, [Na⁺]_i, [Na⁺]_c, [Ca²⁺]_c
NM-C	Nygren et al. model with I_Ca,L multiplied by 1.33, I_to by 2, I_Kur by 0.4, I_Kr by 3, and I_Ks by 3 (from Nygren et al., 2001)
NMf-C	Nygren et al. model with I_Ca,L multiplied by 1.33, I_to by 2, I_Kur by 0.4, I_Kr by 3, and I_Ks by 3 (from Nygren et al., 2001) and with the following concentrations held constant: [K⁺]_i, [K⁺]_c, [Na⁺]_I, [Na⁺]_c, [Ca²⁺]_c
NMf-C2	Nygren et al. model with I_Na multiplied by 0.938, I_Ca,L by 1.37, I_to by 2.07, I_Kur by 0.196, I_Ks by 1.50, I_Kr by 1.56, I_K1 by 1.07, I_Nab by 1.02, and I_Cab by 1.02 (from Syed et al., 2005) and with the following concentrations held constant: [K⁺]_i, [K⁺]_c, [Na⁺]_i, [Na⁺]_c, [Ca²⁺]_c
NM-AF	Nygren et al. model with I_Ca,L multiplied by 0.3, I_to by 0.5, and I_Kur by 0.5 (from Courtemanche et al., 1999)
NMf-AF	Nygren et al. model with I_Ca,L multiplied by 0.3, I_to by 0.5, and I_Kur by 0.5 (from Courtemanche et al., 1999) and with the following concentrations held constant: [K⁺]_i, [K⁺]_c, [Na⁺]_i, [Na⁺]_c, [Ca²⁺]_c
NM-X	Nygren et al. model formulations of ionic concentrations and calcium handling combined with the 12 transmembrane currents of the Courtemanche et al. model
NMf-X	Nygren et al. model formulations of calcium handling combined with the 12 transmembrane currents of the Courtemanche et al. model and with the following concentrations held constant: [K⁺]_i, [K⁺]_c, [Na⁺]_i, [Na⁺]_c, [Ca²⁺]_c

CM	Courtemanche et al. model with [K⁺]_i, [Na⁺]_i held fixed
CM-N	Courtemanche et al. model with I_Ca,L divided by 1.33, I_to by 2, I_Kur by 0.4, I_Kr by 3, and I_Ks by 3 (from Nygren et al., 2001) and with [K⁺]_i, [Na⁺]_i held fixed
CM-AF	Courtemanche et al. model with I_Ca,L multiplied by 0.3, I_to by 0.5, and I_Kur by 0.5 (from Courtemanche et al., 1999) and with [K⁺]_i, [Na⁺]_i held fixed
CM-X	Courtemanche et al. model formulations of calcium handling combined with the 12 transmembrane currents of the Nygren et al. model and with [K⁺]_i, [Na⁺]_i held fixed