Fig. 4.

Nucleic acid-binding properties of human L1 ORF1p. Size exclusion chromatography was done with various nucleic acid substrates (red lines) in the absence (dashed lines) or in the presence (solid lines) of protein (blue solid lines). Elution volumes of the complexes and of the free components are indicated by arrows and dashed gray lines, while apparent concentrations are calculated from the relative absorption properties of the components. M, hL1ORF1p-M; C, hL1ORF1p-C; MC, hL1ORF1p-MC; AluRNA, SA86 (46).