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. 2008 Dec 24;28(52):14293–14300. doi: 10.1523/JNEUROSCI.3301-08.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/2814293-08$15.00/0

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Figure 4. — Effects of orexin A and carbachol. A, B, The 0.1 nmol dose of orexin A tended to improve performance at longer delays for both control (A) and mPF lesioned (B) rats. The overall effect of orexin A was not statistically significant; however, there was a significant interaction between dose and RI. Analyses of simple main effects revealed a significant effect of orexin at RI of 13 s. The effects of orexin A did not interact with the effects of the prefrontal lesion (F < 1). C, D, Carbachol produced dose-dependent impairment significant at the highest dose tested. The effects of carbachol did not interact with the effects of the mPF lesion or the length of the RI (values of F < 1).