The presence of MSI-H or CIMP-high or both (blue, red and yellow shades) is more frequent in tumors with ≥70% LINE-1 methylation (29%=45/153, p=0.0001) and 60-70% LINE-1 methylation (23%=79/349, p=0.002) than in <50% LINE-1 methylated tumors (9.2%=9/98).
CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-H, microsatellite instability-high; MSI-L, microsatellite instability-low; MSS, microsatellite stable.