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. Author manuscript; available in PMC: 2009 Jun 15.
Published in final edited form as: Int J Cancer. 2008 Jun 15;122(12):2767–2773. doi: 10.1002/ijc.23470

Figure 3. Frequencies of MSI/CIMP subtypes of colorectal cancer according to LINE-1 methylation level.

Figure 3

The presence of MSI-H or CIMP-high or both (blue, red and yellow shades) is more frequent in tumors with ≥70% LINE-1 methylation (29%=45/153, p=0.0001) and 60-70% LINE-1 methylation (23%=79/349, p=0.002) than in <50% LINE-1 methylated tumors (9.2%=9/98).

CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-H, microsatellite instability-high; MSI-L, microsatellite instability-low; MSS, microsatellite stable.