Table 3.

Incidence of Worsening of Retinopathy between the End of the Dcct and After Four Years of the Edic Study.^*

Retinal Change†	NO. of Patients‡	Progression of Retinopathy	Adjusted Odds Reduction (95% CI)§	P Value¶
		percent
Severe nonproliferative retinopathy or worse			76 (52-88)	<0.001
Conventional therapy	556	10
Intensive therapy	589	2
Proliferative retinopathy			74 (46-87)	<0.001
Conventional therapy	564	9
Intensive therapy	590	2
Clinically significant macular edema			77 (52-89)	<0.001
Conventional therapy	564	8
Intensive therapy	582	2
Laser therapy (focal or scatter)			77 (45-91)	0.002
Conventional therapy	544	6
Intensive therapy	575	1

^*DCCT denotes Diabetes Control and Complications Trial, EDIC Epidemiology of Diabetes Intervention and Complications, and CI confidence interval.

^†Patients who underwent scatter photocoagulation after the DCCT were counted as having a progression of retinopathy; those who underwent focal photocoagulation were counted as having clinically significant macular edema.

^‡The numbers of patients free of each specific type of worsening at the end of the DCCT are given.

^§The odds reduction is for former intensive therapy as compared with former conventional therapy on the basis of a logistic-regression analysis with adjustment for the level of severity of retinopathy at the end of the DCCT according to the Early Treatment Diabetic Retinopathy Study categories shown in Table 2, plus any previous laser therapy (focal or scatter).

^¶P values were calculated by the likelihood-ratio test.