Table 4.
Incidence of Worsening of Nephropathy between the End of the Dcct and After Four Years of the Edic Study.*
| Renal Complication during EDIC† | NO. of Patients‡ |
Worsening Nephropathy |
Adjusted Odds Reduction (95% CI)§ |
P Value¶ |
|---|---|---|---|---|
| percent | ||||
| Microalbuminuria (urinary albumin excretion rate >28 μg/min) |
53 (26-70) | 0.002 | ||
| Conventional therapy | 573 | 11 | ||
| Intensive therapy | 601 | 5 | ||
| Albuminuria (urinary albumin excretion rate >208 μg/min) |
86 (60-95) | <0.001 | ||
| All patients | ||||
| Conventional therapy | 637 | 5 | ||
| Intensive therapy | 639 | 1 | ||
| Urinary albumin excretion, ≤28 μg/min at end of DCCT |
92 (39-99) | <0.001 | ||
| Conventional therapy | 573 | 2 | ||
| Intensive therapy | 601 | 0 | ||
| Urinary albumin excretion, 29-208 μg/ min at end of DCCT |
80 (27-95) | 0.006 | ||
| Conventional therapy | 64 | 31 | ||
| Intensive therapy | 38 | 8 | ||
*
DCCT denotes Diabetes Control and Complications Trial, EDIC Epidemiology of Diabetes Intervention and Complications, and CI confidence interval.
†
Measurements were performed in year 3 or 4 of the EDIC study (in approximately 50 percent of patients each year).
‡
The numbers of patients free of each specific type of worsening at the end of the DCCT are given.
§
The odds reduction is for former intensive therapy as compared with former conventional therapy on the basis of a logistic-regression analysis with adjustment for the albumin excretion rate at the end of the DCCT.
¶
P values were calculated by the likelihood-ratio test.