Table 2.
Associations of the SNP rs7574865 with Rheumatoid Arthritis.*
| Case-Control Series | Allele | Minor Allele Frequency | Chi-Square Value | P Value | Odds Ratio (95% CI) | |
|---|---|---|---|---|---|---|
| Case Patients | Controls | |||||
| NARAC | G | 0.72 | 0.78 | |||
| T | 0.28 | 0.22 | 15.49 | 8.29×10-5 | 1.37 (1.17-1.60) | |
| Replication series | G | 0.74 | 0.78 | |||
| T | 0.26 | 0.22 | 11.70 | 6.26×10-4 | 1.28 (1.11-1.47) | |
| EIRA | G | 0.75 | 0.78 | |||
| T | 0.25 | 0.22 | 5.08 | 0.02 | 1.18 (1.02-1.36) | |
| Meta-analysis | G | 0.74 | 0.78 | |||
| T | 0.26 | 0.22 | 4.64×10-8 | 1.27 (1.16-1.36) | ||
*
NARAC denotes the North American Rheumatoid Arthritis Consortium, and EIRA Epidemiological Investigation of Rheumatoid Arthritis. The RA meta-analysis was a Mantel-Haenszel analysis; no significant evidence of heterogeneity was identified among the series (P>0.05).