Table 3.
Associations of the SNP rs7574865 with Systemic Lupus Erythematosus.*
| Case-Control Series | Allele | Minor Allele Frequency | Chi-Square Value | P Value | Odds Ratio (95% CI) | |
|---|---|---|---|---|---|---|
| Case Patients | Controls | |||||
| UCSF | G | 0.69 | 0.78 | |||
| T | 0.31 | 0.22 | 19.60 | 9.56×10-6 | 1.61 (1.30-1.99) | |
| ABCoN | G | 0.69 | 0.77 | |||
| T | 0.31 | 0.23 | 12.43 | 4.22×10-4 | 1.52 (1.20-1.91) | |
| MADGC | G | 0.71 | 0.78 | |||
| T | 0.29 | 0.22 | 4.66 | 0.03 | 1.46 (1.03-2.06) | |
| Lupus meta-analysis | G | 0.69 | 0.78 | |||
| T | 0.31 | 0.22 | 1.87×10-9 | 1.55 (1.34-1.79) | ||
*
UCSF denotes the University of California at San Francisco, ABCoN the Autoimmune Biomarkers Collaborative Network, and MADGC the Multiple Autoimmune Diseases Genetics Consortium. The lupus meta-analysis was a Mantel-Haenszel analysis; no significant evidence of heterogeneity was identified among the series (P>0.05).