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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Clin Cancer Res. 2008 Sep 1;14(17):5357–5367. doi: 10.1158/1078-0432.CCR-08-0732

Table 3.

Cathepsins and their inhibitors

graphic file with name nihms72319t3a.jpg
(B) Summary of results of growth inhibition assays with various cathepsin inhibitors
Cell line CTSB inhibitor CTSL inhibitor CTSK inhibitor (A and B)
BT-549 Inhibition of growth at 20 μmol/L No response ND
MDA-MB-231 Inhibition of growth at 20 μmol/L No response ND
MDA-MB-435 Inhibition of growth at 20 μmol/L Morphologic changes at 10 μL ND
MCF10DCIS Inhibition of growth at 20 μmol/L No response No response
MCF10DCIS+stroma Inhibition of growth at 20 μmol/L No response No response

NOTE: (A) Gene names and symbols, serial analysis of gene expression tag numbers (normalized to 50,000) and sequence, UniGene IDs, and chromosomal location are indicated. CD24, CD44, and MUC1 refer to cells purified using these cell surface markers. (B) Cells, inhibitor used, concentration, and results are indicated.

Abbreviations: N, normal; D, DCIS; I, invasive; EPI, epithelial cells; MYOEPI, myoepithelial cells; MYOFIB, myofibroblasts; STR, stromal fibroblasts; ND, not determined.