Table 3.
Clinical pathology data in hemophilia B dogs after AAV-mediated FIX gene therapy
| Dog | WBC, ×103/μL | Hct, % | Platelet, ×103/μL | ALT, U/L | ALP, U/L | BUN, mg/dL | Cr, mg/dL | Alb, g/dL | T. bili. mg/dL | Bile acids, μmol/L | CK, U/L |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Kudzu | 14.6 | 49.3 | 438 | 76 | 28 | 12.1 | 1.0 | 3.5 | < 0.1 | 2.2 | 94 |
| Brad | 11.0 | 48.7 | 636 | 105 | 99 | 13.7 | 0.9 | 4.0 | < 0.1 | 2.8 | 169 |
| Semillon | 9.8 | 45.6 | 648 | 38 | 436 | 9.9 | 0.9 | 3.3 | < 0.1 | 1.9 | 103 |
| Wilbur | 14.9 | 70.6 | 595 | 87 | 554 | 28.9 | 0.9 | 3.4 | 0.2 | ND | 106 |
| Sauvignon | 13.7 | 45.5 | 737 | 44 | 66 | 10.6 | 0.8 | 3.7 | 0.2 | 9.4 | 242 |
| Normal range | 6.0-17.0 | 37.0 -55.0 | 164-510 | 26-200 | 3.5-95 | 10-25 | 0.0-1.3 | 2.6-3.5 | 0.1-0.3 | 0.1-6.5 | 92-357 |
Blood samples were obtained 5.5-6 years after vector administration. Hct indicates hematocrit; ALT, alanine aminotransferase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; Cr, creatinine; Alb, albumin; T. bili, total bilirubin; CK, creatine kinase; and ND, not done.