Table 1.

Gene mutations in sarcomere-related genes in HCM.

Gene	Protein	Frequency (%)
MYH7	Cardiac myosin heavy chain beta	30–50
MYBPC3	Myosin binding protein C	20–40
TNNT2	Cardiac troponin T	5–20
TNNI3	Cardiac troponin I	<5
TPM1	α-tropomyosin	<5
MYL2	Cardiac myosin light chain 2, regulatory	<3
MYL3	Cardiac myosin light chain 3, essential	<1
ACTC	Cardiac actin	<1
TTN	Titin	rare
MYH6	α-myosin heavy chain	rare