Fig. 4.

Concentration-response relationships for in vitro inhibition of AChE in different tissues from male and female guinea pigs at PND5–10. The AChE activity (AU/min/mg protein) measured in brain extracts, RBCs, plasma, or whole blood each pooled from six male or six female neonatal guinea pigs was taken as 100% and used to normalize the AChE activity measured after in vitro exposure of the tissues to a given nerve agent concentration. The resulting concentration-response relationships were fitted to the Hill equation. Data points and error bars are mean and S.E.M. of results obtained from triplicate experiments.