Fig. 6.

Correlational analysis of the relationship between LD₅₀ values and IC₅₀ values for in vitro inhibition of AChE in various tissues from neonatal and prepubertal guinea pigs of both sexes. Double logarithmic plots of the median lethal doses (LD₅₀ values) of each nerve agent for neonatal and prepubertal guinea pigs of both sexes versus the corresponding in vitro concentrations of the nerve agents needed to inhibit by 50% the AChE activity in brain extracts, plasma, RBCs, or whole blood. The symbol clusters labeled 1, 2, and 3 correspond to VX, soman, and sarin, respectively. In each graph, the solid lines represent the linear regression of the data points, and the dotted lines illustrate the 95% confidence intervals of the regression. The Pearson coefficients (r²) are shown at the bottom right of each graph. LD₅₀ values for prepubertal male guinea pigs are from the literature (Shih and McDonough, 2000).