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Model for colonic fluid and ion transport in the setting of colitis. Both surface and crypt transport processes are compromised compared to the situation in healthy tissues (compare with Figure 3). The lack of crypt chloride and fluid secretion results in crypt stagnation, the accumulation of toxins, and reduced barrier function in this site. The lack of adequate absorption across surface cells results in a failure to salvage luminal fluid, and the clinical finding of diarrhea.
