. 2008 Nov 4;328(2):448–457. doi: 10.1124/jpet.108.146464

TABLE 3.

Effect of cis- and trans-3-ACPBPA at GABA receptors expressed in X. laevis oocytes The IC₅₀ values of cis- and trans-3-ACPBPA on GABA_Cρ1 and _ρ2 receptors expressed in X. laevis oocytes using the concentration of GABA as 1 μM are shown. The values in parentheses are log IC₅₀ ± S.E.M.

Compound	GABA_A(α₁β₂γ_2L)^a	GABA_B(1b,2)^b	IC₅₀
Compound	GABA_A(α₁β₂γ_2L)^a	GABA_B(1b,2)^b	GABA_Cρ1^c	GABA_Cρ2^c
	%		μM
cis-3-ACPBPA	33 ± 3	27 ± 3	5.062 (0.7043 ± 0.025)	11.08 (1.044 ± 0.086)
trans-3-ACPBPA	28 ± 5	35 ± 5	72.58 (1.861 ± 0.043)	189.7 (2.278 ± 0.034)

Percentage inhibition cis-3-ACPBPA (1 mM) and trans-3-ACPBPA (1 mM) against an EC₅₀ concentration of GABA (60 μM) at α₁β₂γ_2L expressed in X. laevis oocytes

Percentage inhibition cis-3-ACPBPA (1 mM) and trans-3-ACPBPA (1 mM) against an EC₅₀ concentration of GABA (3 μM) at GABA_B(1b,2) coupled to GIRK1 and GIRK4 expressed in X. laevis oocytes