Figure 7. Increased sensitivity of orexin overexpression mouse to leptin.
(A) The body weight changes during chronic ICV injection of leptin (2ug/day) for 14 days, CAG/orexin mice on a low fat diet show larger weight loss compared with wild-type mice (p<0.05).
(B) Daily food intake of CAG/orexin mice during chronic injection of leptin is smaller than that of wild-type mice.
(C) Hypothalamic gene expressions at the end of leptin administration. 6–8 mice per group. Data are expressed as means ± SEM. *p<0.05