Table 4.
Relative risks (RRs) and 95% confidence intervals (CIs) for the association between GSTM1, GSTT1, and NAT2 genotype and epithelial ovarian cancer risk in the New England Case-Control Study (NECC) and the Nurses' Health Study (NHS)
| NECC† |
NHS† |
Pooled‡ |
|||||
|---|---|---|---|---|---|---|---|
| Cases (%) | Ctrls (%) | RR (95% CI) | Cases (%) | Ctrls (%) | RR (95% CI) | RR (95% CI) | |
| N* | 1175 | 1202 | 210 | 600 | |||
| GSTM1 genotype | |||||||
| Present | 573 (49.1) | 567 (47.4) | 1.00 (ref.) | 102 (52.3) | 268 (48.5) | 1.00 (ref.) | 1.00 (ref.) |
| Null | 594 (50.9) | 628 (52.6) | 0.93 (0.79, 1.10) | 93 (47.7) | 285 (51.5) | 0.83 (0.58, 1.17) | 0.91 (0.78, 1.06) |
| GSTT1 genotype | |||||||
| Present | 919 (78.8) | 938 (78.5) | 1.00 (ref.) | 157 (81.3) | 439 (78.8) | 1.00 (ref.) | 1.00 (ref.) |
| Null | 247 (21.2) | 257 (21.5) | 0.98 (0.80, 1.21) | 36 (18.7) | 118 (21.2) | 0.87 (0.57, 1.33) | 0.96 (0.80, 1.16) |
| NAT2 genotype | |||||||
| Rapid/intermediate acetylator | 387 (36.8) | 405 (36.1) | 1.00 (ref.) | 77 (41.0) | 182 (33.0) | 1.00 (ref.) | 1.00 (ref.) |
| Slow acetylator | 665 (63.2) | 717 (63.9) | 0.97 (0.81, 1.15) | 111 (59.0) | 369 (67.0) | 0.65 (0.45, 0.95) | 0.82 (0.57, 1.20) |
| Combined GSTM1/GSTT1 genotype | |||||||
| Both present | 445 (38.2) | 430 (36.0) | 1.00 (ref.) | 81 (44.3) | 206 (39.2) | 1.00 (ref.) | 1.00 (ref.) |
| M1 null, T1 present | 474 (40.7) | 508 (42.5) | 0.91 (0.76, 1.10) | 68 (37.2) | 208 (39.5) | 0.82 (0.54, 1.22) | 0.89 (0.75, 1.06) |
| M1 present, T1 null | 128 (11.0) | 137 (11.5) | 0.94 (0.71, 1.24) | 17 (9.3) | 49 (9.3) | 0.98 (0.52, 1.84) | 0.94 (0.73, 1.22) |
| Both null | 119 (10.2) | 120 (10.0) | 0.94 (0.70, 1.26) | 17 (9.3) | 63 (12.0) | 0.65 (0.34, 1.24) | 0.88 (0.67, 1.15) |
| Combined GSTM1/NAT2 genotype | |||||||
| GSTM1 present, NAT2 rapid | 195 (18.6) | 188 (16.9) | 1.00 (ref.) | 37 (21.0) | 85 (16.4) | 1.00 (ref.) | 1.00 (ref.) |
| GSTM1 null, NAT2 rapid | 189 (18.1) | 214 (19.2) | 0.82 (0.61, 1.09) | 35 (19.9) | 91 (17.5) | 0.96 (0.53, 1.74) | 0.84 (0.65, 1.09) |
| GSTM1 present, NAT2 slow | 315 (30.1) | 343 (30.7) | 0.86 (0.66, 1.11) | 56 (31.8) | 161 (31.0) | 0.87 (0.51, 1.50) | 0.86 (0.68, 1.09) |
| GSTM1 null, NAT2 slow | 347 (33.2) | 371 (33.2) | 0.88 (0.68, 1.14) | 48 (27.3) | 183 (35.2) | 0.57 (0.33, 0.98) | 0.76 (0.50, 1.14) |
| Combined GSTT1/NAT2 genotype | |||||||
| GSTT1 present, NAT2 rapid | 296 (28.3) | 312 (28.0) | 1.00 (ref.) | 52 (29.7) | 144 (27.5) | 1.00 (ref.) | 1.00 (ref.) |
| GSTT1 null, NAT2 rapid | 88 (8.4) | 90 (8.1) | 1.03 (0.73, 1.45) | 17 (9.7) | 30 (5.7) | 1.55 (0.76, 3.16) | 1.11 (0.81, 1.52) |
| GSTT1 present, NAT2 slow | 519 (49.7) | 562 (50.4) | 0.97 (0.79, 1.19) | 90 (51.4) | 270 (51.6) | 0.87 (0.57, 1.33) | 0.95 (0.79, 1.14) |
| GSTT1 null, NAT2 slow | 142 (13.6) | 152 (13.6) | 0.98 (0.74, 1.31) | 16 (9.1) | 79 (15.1) | 0.51 (0.26, 0.99) | 0.76 (0.40, 1.43) |
*
Frequencies do not add up to total N due to missing genotype data
†
Unconditional (NECC) and conditional (NHS) logistic regression adjusted for age, study center (NECC only), duration of oral contraceptive use (months), parity (continuous), tubal ligation, body mass index (kg/m2, continuous), and duration of postmenopausal hormone use (months)
‡
P-values for tests for heterogeneity comparing the NECC and NHS results were all >0.06