Table 1.

Lifetime Symptoms by Gender and Site

	Total
Symptom	F (N=268)	M (N=371)	P-value	St. Louis (N=297)	Miami (N=186)	Sydney (N=156)	P-value
Major role obligations	31.0	22.0	.010	20.9	23.7	37.8	<.001
Physically hazardous	51.7	50.5	NS	49.8	51.1	53.2	NS
Legal problems	3.0	5.7	NS	3.4	7.0	3.9	NS
Problems with family	24.4	20.1	NS	16.5	24.2	29.5	.004
Problems with friends	19.9	15.5	NS	15.8	19.4	18.0	NS
Problems at school/work	12.6	10.9	NS	8.8	11.3	17.3	.026
Fights from ecstasy use	3.0	2.2	NS	3.0	1.6	2.6	NS
Continued use despite probs.	31.4	27.2	NS	25.9	30.7	32.7	NS
Tolerance	51.3	48.6	NS	43.1	56.5	54.5	.007
Withdrawal – Behavioral	85.2	77.7^a	.017	77.4	80.7	87.8	.028
Withdrawal – Somatic	52.0	53.8	NS	48.5	55.4	59.0	NS
Withdrawal – Neurological	57.2	49.7	NS	51.2	56.5	51.9	NS
Withdrawal – Avoidance	16.6	12.5	NS	12.5	16.7	14.8	NS
Use more XTC than intended	48.0	38.9	.021	37.4	47.9	46.8	.038
Persistent desire quit cut down	20.7	14.4	.038	14.1	18.3	21.2	NS
Time spent acquiring, using, recovering from XTC use	56.1	55.2	NS	48.2	62.4	61.5	.002
Give up social, recreational occupational activities	29.5	22.3	.038	20.1	24.7	34.6	.006
Physical health problems – somatic	87.5	85.1	.387	84.2	89.3	85.9	NS
Physical health problems –neurological	62.0	59.8	.572	58.6	57.5	68.6	NS
Physical health problems –non specific	30.6	26.4	NS	20.9	28.5	41.7	<.001
Continued use w physical health problems	80.1	78.3	NS	76.8	81.2	80.8	NS
Emotional psych problems –Mood change	78.6	75.8	NS	74.4	79.0	79.5	NS
Emotional psych problems –thought disturbance	75.7	74.7	NS	72.4	82.8	71.2	.015
Continued use even with emotional psych problems	83.4	75.3	.013	76.1	83.9	77.6	NS

Note. All of the comparison tests based on χ² proportional test statistic.