Table 2. Compilation of key biological pathways and proteins that are altered in animal models of Alzheimer's and Parkinson's Diseases determined by proteomicsa.
| Biological Function/Protein(s) | AD | PD | ||
|---|---|---|---|---|
| Model(s) | References | Model(s) | References | |
| Amino Acid Synthesis | ||||
| D-3-phosphoglycerate dehydrogenase | GSKβ | Tilleman et al. 2002 | --- | --- |
| Aspartate aminotransferase | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Dimethylarginine dimethylaminohydrolase 1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Glutamate oxaloacetate transaminase 2 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Glutamine synthetase | Aβ (1-42) injected rat, GSKβ | Boyd-Kimball et al. 2005, Tilleman et al. 2002 | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005, Diedrich et al. 2008 |
| Henna | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Serine racemase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Blood pH Regulation | ||||
| Carbonic anhydrase II | P301L tau | David et al. 2007 | A30P α-synuclein mice, parkin KO mice | Poon et al. 2005c, Periquet et al. 2005 |
| Cellular Transport | ||||
| ADP, ATP carrier protein | --- | --- | MPTP mice | Jin et al. 2005 |
| ATPase, H+ transporting, V1 subunit 5 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Calcium ATPase at 60A | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Complexin 1 | GSKβ | Tilleman et al. 2002 | MPTP mice | Diedrich et al. 2008 |
| Complexin 2 | --- | --- | MPTP mice | Jin et al. 2005, Diedrich et al. 2008 |
| Dynamin-1 | APP/Sw | Shin et al. 2004 | parkin KO mice | Periquet et al. 2005 |
| Ferritin heavy chain | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Ferritin 1 heavy chain homologue | --- | --- | A30P Drosophila | Xun et al. 2007a |
| G protein β-subunit 13F | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Globin 1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Larval serum protein 2b | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Na+/K+ transporting ATPase α-1 chain | --- | --- | MPTP mice | Jin et al. 2005 |
| Na+/K+ transporting ATPase α-2 chain | --- | --- | MPTP mice | Jin et al. 2005 |
| Na+/K+ transporting ATPase α-3 chain | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005 |
| Neutral amino acid transporter A | --- | --- | MPTP mice | Jin et al. 2005 |
| Phosphate carrier protein | --- | --- | MPTP mice | Jin et al. 2005 |
| Rho GDP-dissociation inhibitor 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Septin 2 or 6 homologue | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Septin 5 | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2005 |
| Septin 7 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Septin 11 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Septin-like protein KIAA0202 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Serum albumin precursor | Swe/Lon | Sizova et al. 2007 | --- | --- |
| Sorting nexin 5 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Transferrin | P301L tau | David et al. 2007 | --- | --- |
| Vesicular fusion protein | GSKβ | Tilleman et al. 2002 | --- | --- |
| Cytoskeletal Structural Integrity | ||||
| 14-3-3ε | --- | --- | MPTP mice | Jin et al. 2005 |
| 14-3-3γ | --- | --- | MPTP mice | Diedrich et al. 2008 |
| 14-3-3ζ | Aβ (1-42) injected rat | Boyd-Kimball et al. 2005 | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005 |
| α-internexin | GSKβ | Tilleman et al. 2002 | MPTP mice | Diedrich et al. 2008 |
| β-actin | P301L tau | David et al. 2007 | hemiparkinsonian rat, α-synuclein C. elegans, parkin KO mice, MPTP mice | Deluliius et al. 2005, Ichibangase et al. 2008, Periquet et al. 2005, Diedrich et al. 2008 |
| Actin related protein 2/3 complex, subunit 5-lik | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Adenyl cyclase-associated protein 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| ARP2/3 complex 20 kDa subunit | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Capping protein of actin filament | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Cofilin | --- | --- | MPTP mice | Jin et al. 2005, Diedrich et al. 2008 |
| Fascin | GSKβ | Tilleman et al. 2002 | --- | --- |
| Glial fibrillary acidic protein | APP/Sw, Swe/Lon | Shin et al. 2004, Sizova et al. 2007 | --- | --- |
| Histone H4 replacement | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Kinesin heavy chain | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Microtubule associated protein 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Muscle LIM protein at 60A | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Muscle specific protein 300b | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Myosin alkali light chain 1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Paramyosin | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Profilin | SAMP8 | Poon et al. 2005a | --- | --- |
| Profilin II splice isoform IIB | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Similar to ARP1 actin-related protein 1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Similar to myosin Vb | --- | --- | MPTP mice | Jin et al. 2005 |
| Spectrin α-chain | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Spectrin β-chain | --- | --- | MPTP mice | Jin et al. 2005 |
| Stathmin 1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Transketolase | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Troponin C | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Troponin T | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Tubulin chain 15/α | Aβ (1-42) injected rat | Boyd-Kimball et al. 2005 | --- | --- |
| Tubulin α-1 chain | GSKβ | Tilleman et al. 2002 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Tubulin α-1a chain | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Tubulin α-2 chain | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Tubulin α-4 chain | P301L tau | David et al. 2007 | MPTP mice | Jin et al. 2005, Diedrich et al. 2008 |
| Tubulin β chain 1 | GSKβ | Tilleman et al. 2002 | --- | --- |
| Tubulin β chain A | Swedish human mutant transgenic rat | Wilson et al. 2005 | MPTP mice | Diedrich et al. 2008 |
| Tubulin β chain B | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Tubulin β-4 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Tubulin polymerization-promoting protein | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Upheld | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Vinculin | --- | --- | L-DOPA mice | Valastro et al. 2007 |
| Energy Metabolism | ||||
| α-enolase | APP/Sw, GSKβ, SAMP8 | Shin et al. 2004, Tilleman et al. 2002, Poon et al. 2005b | A30P α-synuclein mice; hermiparkinsonia n rat, MPTP mice | Poon et al. 2005c, DeIuliius et al. 2005, Diedrich et al. 2008 |
| γ-enolase | APP/Sw | Shin et al. 2004 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Aconitase | APP/Sw | Shin et al. 2004 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Aconitate hydratase | MPTP mice | Diedrich et al. 2008 | ||
| Aldolase 3 | SAMP8 | Poon et al. 2005a | --- | --- |
| Aldose reductase | GSKβ | Tilleman et al. 2002 | --- | --- |
| ATP synthase subunit D | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| ATP synthase α chain | APP/Sw | Shin et al. 2004 | in vitro dopamine quinone treated rats, parkin KO mice, A30P Drosophila, MPTP mice | Van Laar et al. 2008, Periquet et al. 2005, Xun et al. 2007a, Diedrich et al. 2008 |
| ATP synthase α chain, mitochondrial | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| ATP synthase β chain, mitochondrial | --- | --- | parkin KO mice, A53T Drosophila, A30P Drosophila | Periquet et al. 2005, Xun et al. 2008, Xun et al. 2007a |
| ATP synthase γ chain, mitochondrial | --- | --- | MPTP mice, A30P Drosophila | Jin et al. 2005, Xun et al. 2007a |
| ATP α | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Citrate synthase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Creatine kinase β chain | GSKβ | Tilleman et al. 2002 | MPTP mice | Jin et al. 2005 |
| Creatine kinase | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Cytochrome c, oxidase | --- | --- | MPTP mice | Jin et al. 2005 |
| Cytochrome c, oxidase subunit 5A | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Cytochrome c, oxidase subunit 6B1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Cytochrome c1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Cytochrome P450 reductase | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Dihydrolipoadmide dehydrogenase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Fructose-bisphosphate aldolase | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Fructose-bisphosphate aldolase A | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Fructose-bisphosphate aldolase C | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005, Diedrich et al. 2008 |
| Glyceraldehyde-3-phosphate dehydrogenase | APP/Sw, Aβ (1-42) injected rat | Shin et al. 2004, Boyd-Kimball et al. 2005 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Glycerol-3-phosphate dehydrogenase | --- | --- | L-DOPA mice, A53T Drosophila, MPTP mice | Valastro et al. 2007, Xun et al. 2008, Jin et al. 2005 |
| GTP:AMP phosphtransferase mitochondrial | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Hexokinase | --- | --- | MPTP mice | Jin et al. 2005 |
| Isocitrate dehydrogenase NADH cytoplasm | P301L tau, GSKβ | David et al. 2007, Tilleman et al. 2002 | --- | --- |
| Lactate dehydrogenase | SAMP8 | Poon et al. 2005b | parkin KO mice, A53T Drosphila | Periquet et al. 2005, Xun et al. 2008 |
| Malate dehydrogenase | APP/Sw | Shin et al. 2004 | parkin KO mice | Periquet et al. 2005 |
| Mitochondrial creatine kinase | SAMP8 | Poon et al. 2005b | --- | --- |
| NADH dehydrogenase | P301L tau | David et al. 2007 | --- | --- |
| NADH dehydrogenase 1 α subcomplex 8 | --- | --- | MPTP mice | Jin et al. 2005 |
| NADH dehydrogenase, 75 kDa subunit | --- | --- | in vitro dopamine quinone treated rats | Van Laar et al. 2008 |
| NADH dehydrogenase Fe-S protein 8 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| NADH ubiquinone oxidoreductase 23 kDa subunit | GSKβ | Tilleman et al. 2002 | --- | --- |
| NADH ubiquinone oxidoreductase 24 kDa subunit | GSKβ | Tilleman et al. 2002 | --- | --- |
| NADH ubiquinone oxidoreductase 39 kDa subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| NADH ubiquinone oxidoreductase 49 kDa subunit | GSKβ | Tilleman et al. 2002 | parkin KO mice | Periquet et al. 2005 |
| NADH ubiquinone oxidoreductase 51 kDa subunit | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| NADH ubiquinone oxidoreductase 75 kDa subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| NADH ubiquinone oxidoreductase B15 subunit | P301L tau | David et al. 2007 | ||
| Phosphofructokinase | --- | --- | A30P Drosophila, MPTP mice | Xun et al. 2007a, Diedrich et al. 2008 |
| Phosphoglucomutase | GSKβ | Tilleman et al. 2002 | --- | --- |
| Phosphoglycerate kinase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Phosphoglycerate mutase 1 | P301L tau, Aβ (1-42) injected rat, Swedish mutant human transgenic rat | David et al. 2007, Boyd-Kimball et al. 2005, Wilson et al. 2005 | in vitro dopamine quinone treated rats, MPTP mice | Van Laar et al. 2008, Diedrich et al. 2008 |
| Phosphoglycerate mutase B | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Phospoglycerate kinase 1 | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Pyruvate dehydrogenase | Aβ (1-42) injected rat | Boyd-Kimball et al. 2005 | A30P α-synuclein mice | Poon et al. 2005c |
| Pyruvate dehydrogenase E1 component α subunit | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005, Diedrich et al. 2008 |
| Pyruvate dehydrogenase E1 component β subunit | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Pyruvate kinase | APP/Sw, Swe/Lon | Shin et al. 2004, Sizova et al. 2007 | parkin KO mice, A30P Drosophila, MPTP mice | Periquet et al. 2005, Xun et al. 2007a, Diedrich et al. 2008 |
| Pyruvate kinase 3 | --- | --- | MPTP mice | Jin et al. 2005 |
| Succinate dehydrogenase | GSKβ | Tilleman et al. 2002 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Triosephosphate isomerase | --- | --- | MPTP mice | Jin et al. 2005 |
| Vacuolar ATP synthase subunit G1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Vacuolar ATP synthase subunit β-brain isoform | GSKβ | Tilleman et al. 2002 | --- | --- |
| Vacuolar H+ ATPase E1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Energy Metabolism/Mitochondrial Function | ||||
| Acetyl-CoA acetyltransferase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Acetyl-CoA acetyltransferase, mitochondrial | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Mitochondrial import inner membrange translocase subunit TIM13 A | --- | --- | MPTP mice | Jin et al. 2005 |
| Succinyl-CoA ligase β-chain, mitochondrial | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Ubiquinol-cytochrone c reductase complex 11kDa protein, mitochondrial precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Ubiquinol-cytochrone c reductase complex core protein 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Ubiquinol-cytochrone c reductase complex core protein 2 | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Ubiquitin thiolesterase L1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Inflammation/Immune Response | ||||
| CD166 antigen precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Complement c1 q | Swe/Lon | Sizova et al. 2007 | --- | --- |
| Inducible nitric oxide synthase | --- | --- | MPTP mice | McLaughlin et al. 2006 |
| Low-affinity immunoglobulin ε FC receptor | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Macrophage migration inhibitory factor | --- | --- | MPTP mice | Jin et al. 2005 |
| Lipid Metabolism | ||||
| ACAT | Swe/Lon | Sizova et al. 2007 | --- | --- |
| Acyl carrier protein, mitochondrial precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Acyl-CoA dehydrogenase, very long chain specific | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Acyl-CoA oxidase 2, peroxisomal | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Acyl-CoA thioester hydrolase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Acyl-protein thioesterase 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Annexin 5 | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| ApoE precursor | Swe/Lon | Sizova et al. 2007 | axotomized rats | Rite et al. 2007 |
| Lysophospholipase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Phosphatidylethanolamine-binding protein | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Propionyl CoA carboxylase α-chain | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Yippee interacting protein 2 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Mitochondrial Function | ||||
| Atp5b protein | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Dihydrolipoyl dehydrogenase, mitochondrial | --- | --- | MPTP mice | Jin et al. 2005 |
| DJ-1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Mitochondrial matrix protein P1 precursor | GSKβ | Tilleman et al. 2002 | --- | --- |
| Mitochondrial precursor proteins import receptor | --- | --- | MPTP mice | Jin et al. 2005 |
| Mitofilin | --- | --- | in vitro dopamine quinone treated rats | Van Laar et al. 2008 |
| Voltage dependent anion channel 2 | --- | --- | in vitro dopamine quinone treated rats, MPTP mice | Van Laar et al. 2008, Jin et al. 2005, Diedrich et al. 2008 |
| Voltage dependent anion-selective channel protein 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Neurotransmission Related | ||||
| 4-Aminobutyrate aminotransferase, mitochondrial | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Comatose | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Excitatory amino acid transporter 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Gamma-aminobutyric acid | --- | --- | MPTP mice | Jin et al. 2005 |
| n-Synaptobrevin | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Ras opposite | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Sodium- and chloride-dependent | ||||
| GABA transporter 3 homolog | --- | --- | MPTP mice | Jin et al. 2005 |
| Tyrosine 3-hydroxylase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Oxidative Stress/Antioxidant Defense | ||||
| Antioxidant protein 2 | GSKβ | Tilleman et al. 2002 | --- | --- |
| Carbonyl reductase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Glutathione-s-transferase | GSKβ | Tilleman et al. 2002 | parkin KO mice | Periquet et al. 2005 |
| Glutathione-s-transferase Mu 3 | --- | --- | MPTP mice | Jin et al. 2005 |
| Glyoxalase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Haptoglobin | --- | --- | axotomized rats | Rite et al. 2007 |
| Peroxidase | MPTP mice | Diedrich et al. 2008 | ||
| Peroxiredoxin 1 | MPTP mice | Diedrich et al. 2008 | ||
| Peroxiredoxin 2 | SAMP8 | Poon et al. 2005a | MPTP mice | Diedrich et al. 2008 |
| Peroxiredoxin 2A | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Peroxiredoxin 2B | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Peroxiredoxin 3 | MPTP mice | Diedrich et al. 2008 | ||
| Peroxiredoxin 5 | P301L tau | David et al. 2007 | MPTP mice | Diedrich et al. 2008 |
| Peroxiredoxin 6 | Swe/Lon | Sizova et al. 2007 | MPTP mice | Diedrich et al. 2008 |
| PHGPx | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Superoxide dismutase 1 (Cu-Zn) | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Superoxide dismutase 2 (Mn) | --- | --- | in vitro dopamine quinone treated rats, A53T Drosphila | Van Laar et al. 2008, Xun et al. 2008 |
| Thioredoxin reductase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Thioredoxin-like protein 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Protein Biosynthesis | ||||
| 40S ribosomal protein SA | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Ribosomal protein S12 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Ribobsomal protein S17 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Ribosomal protein large subunits 13, 23, 30, and 43 | --- | --- | α-synuclein C. elegans | Ichibangase et al. 2008 |
| Ribosomal protein S3A | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Ribosomal protein small subunit 8 | --- | --- | A53T Drosophila | Xun et al. 2008 |
| Ribosomal proteins large subunits 6, 14, and 23A | --- | --- | A53T Drosophila | Xun et al. 2008 |
| Similar to 60S ribosomal protein L18a | --- | --- | MPTP mice | Jin et al. 2005 |
| Stab | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Threonyl tRNA synthetase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Tyrosyl tTNA synthetase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| RNA Processing/Transcription Related | ||||
| ATP-dependent RNA helicase DDX19, dead box protein | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Elongation factor 1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Elongation factor 1 R48D | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Elongation factor 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Poly(rC)binding protein | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Probable ATP-dependent RNA helicase p47 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Similar to transcription elongation factor B polypeptide 3 | --- | --- | MPTP mice | Jin et al. 2005 |
| Transcriptional associated protein purine rich single stranded DNA binding protein α | GSKβ | Tilleman et al. 2002 | --- | --- |
| Zinc finger protein TZF-L | --- | --- | MPTP mice | Jin et al. 2005 |
| Signal Transduction | ||||
| 2′,3′-Cyclic nucleotide 3′-phosphodiesterase | --- | --- | MPTP mice | Jin et al. 2005 |
| Calbindin | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Calcium/calmodulin-dependent 3′,5′-cyclic nucleotide phosphodiesterase | --- | --- | MPTP mice | Jin et al. 2005 |
| Calcium/calmodulin-dependent protein kinase type II β chain | --- | --- | MPTP mice | Jin et al. 2005 |
| Calretinin | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| CaMK-II alpha subunit | Swe/Lon | Sizova et al. 2007 | --- | --- |
| CaMK-II of P11798 calcium/calmodulin dependent kinase type II α chain | --- | --- | MPTP mice | Jin et al. 2005 |
| cAMP/cGMP diesterase | --- | --- | MPTP mice | Jin et al. 2005 |
| Clathrin coat assembly protein AP50 | --- | --- | MPTP mice | Jin et al. 2005 |
| Dual specificity mitogen-actived protein kinase kinase 1 | GSKβ | Tilleman et al. 2002 | --- | --- |
| G protein, γ 2 subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| G protein, γ 12 subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| MAGUK p55 subfamily member 2 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| MAGUK p55 subfamily member 3 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| MAGUK p55 subfamily member 6 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Mitogen-activated protein kinase 1 | GSKβ | Tilleman et al. 2002 | --- | --- |
| Peptidylprolyl cis-trans isomerase | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Phosphatidyl inotisol transferase α isoform | GSKβ | Tilleman et al. 2002 | --- | --- |
| Protein kinase C and casine kinase substrate in neurons protein 1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Protein kinase C, γ type | --- | --- | MPTP mice | Jin et al. 2005 |
| Protein phosphatase 2 regulatory subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| Protein TYPROTEIN tyrosine kinase 9-like | --- | --- | MPTP mice | Jin et al. 2005 |
| Protein tyrosine phosphatase, non receptor type 1-1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Proto-oncogene C-crk | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Purkinje cell protein 4 | --- | --- | MPTP mice | Skold et al. 2006 |
| Ras-related C3 botulinum toxin substrate 1 | --- | --- | NADH ubiquinone oxidoreductase 49 kDa subunit | |
| Receptor of activated protein kinase C1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Ser/Thr protein phosphatase 1 catalytic γ subunit | GSKβ | Tilleman et al. 2002 | --- | --- |
| Ser/Thr protein phosphatase 2B catalytic subunit, α isoform | GSKβ | Tilleman et al. 2002 | parkin KO mice | Periquet et al. 2005 |
| Ser/Thr protein phosphatase PP1-β catalytic subunit | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Ser/Thr protein phosphatase PP1-γ catalytic subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| Similar to peptidyl-prolyl cis-trans isomerase | --- | --- | MPTP mice | Jin et al. 2005 |
| Sumo-1 activating enzyme subunit 2 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| β-Adrenergic receptor kinase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Stress Related Proteins/Chaperones | ||||
| αβ-crystallin | --- | --- | L-DOPA mice | Valastro et al. 2007 |
| Aconitate hydratase, mitochondrial | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Calnexin 99A | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Glucose-regulated protein 78 kDa | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Heat shock 70-related protein APG-1 | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Heat shock cognate 71 kDa protein | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Heat shock cognate 73 | --- | --- | MPTP mice | Jin et al. 2005 |
| Heat shock protein 1 | MPTP mice | Diedrich et al. 2008 | ||
| Heat shock protein 60 | Aβ (1-42) injected rat | Boyd-Kimball et al. 2005 | MPTP mice | Diedrich et al. 2008 |
| Heat shock protein 70 | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Heat shock protein 90b | GSKβ | Tilleman et al. 2002 | --- | --- |
| Heat shock protein cognate 3 | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Heat shock related 70 kDa protein 2 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Mortalin (mtHSP70, GRP75) | ApoE4 | Osorio et al. 2007 | in vitro dopamine quinone treated rats | Van Laar et al. 2008 |
| Rtn11 | A53T Drosphila | Xun et al. 2008 | ||
| Stress protein 70 | P301L tau | David et al. 2007 | parkin KO mice | Periquet et al. 2005 |
| T-complex protein 1 ε subunit | GSKβ | Tilleman et al. 2002 | MPTP mice | Jin et al. 2005 |
| T-complex protein 1 θ and β subunits | GSKβ | Tilleman et al. 2002 | --- | --- |
| T-complex protein 1, α-subunit B | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Transgelin-3 | P301L tau | David et al. 2007 | MPTP mice | Diedrich et al. 2008 |
| Transthyretin | --- | --- | axotomized rat | Rite et al. 2007 |
| Synaptic/Axonal Integrity | ||||
| Clipin E/coronin 6 type C | --- | --- | MPTP mice | Jin et al. 2005 |
| Coronin 1a | SAMP8 | Poon et al. 2005a | --- | --- |
| Coronin like protein P57 fragment | GSKβ | Tilleman et al. 2002 | MPTP mice | Jin et al. 2005 |
| Dihydropyrimidase-like 2 | APP/Sw, Swe/Lon, P301L tau, GSKβ, SAMP8 | Shin et al. 2004, Sizova et al. 2007, David et al. 2007, Tilleman et al., 2002, Poon et al. 2005b | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Dihydropyrimidase-like 5 | P301L tau | David et al. 2007 | MPTP mice | Jin et al. 2005, Diedrich et al. 2008 |
| Micotubule-associated protein 1B | MPTP mice | Diedrich et al. 2008 | ||
| Myelin basic protein | P301L tau | David et al. 2007 | MPTP mice | Jin et al. 2005 |
| N-ethylmaleimide sensitive fusion protein | Swe/Lon | Sizova et al. 2007 | parkin KO mice | Periquet et al. 2005 |
| Neurofascin precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Neurofilament triplet L protein | SAMP8, GSKβ | Poon et al. 2005b, Tilleman et al. 2002 | MPTP mice | Diedrich et al. 2008 |
| Neurofilament M | MPTP mice | Diedrich et al. 2008 | ||
| Stoned | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Synapsin-2 | P301L tau | David et al. 2007 | MPTP mice | Diedrich et al. 2008 |
| Synaptonal associated protein | GSKβ | Tilleman et al. 2002 | --- | --- |
| Synaptophysin | --- | --- | MPTP mice | Jin et al. 2005 |
| Synaptotagamin I | Swe/Lon | Sizova et al. 2007 | ||
| Syntaxin 1B | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Syntaxin-binding protein 1 | --- | --- | parkin KO mice, MPTP mice | Periquet et al. 2005, Jin et al. 2005 |
| Ubiquitin/Proteaosome Degradation | --- | --- | ||
| 26S protease regulatory subunit 4 | --- | --- | MPTP mice | Jin et al. 2005 |
| α-synuclein | MPTP mice | Diedrich et al. 2008 | ||
| Deubiquitinating enzyme OTUB1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| NEDD-4 | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Proteasome complex activator subunit 2 | APP/Sw | Shin et al. 2004 | --- | --- |
| Proteasome subunit α-2 | --- | --- | L-DOPA mice | Valastro et al. 2007 |
| Proteasome subunit α-3 | P301L tau | David et al. 2007 | --- | --- |
| Proteasome subunit β type 5 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Ubiquitin activating enzyme 1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Ubiquitin carboxyterminal hydrolase L1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Ubiquitin-like protein Nedd8 | MPTP mice | Diedrich et al. 2008 | ||
| Vasopressin activated calcium mobilizing receptor (CUL5) | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Others | ||||
| 3-oxoacid CoA transferase 1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| 11 days embryo cDNA | --- | --- | MPTP mice | Jin et al. 2005 |
| α-1-antitrypsin 1-5 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| β-synuclein | Aβ (1-42) injected rat | Boyd-Kimball et al. 2005 | MPTP mice | Diedrich et al. 2008 |
| ADAM22 | --- | --- | MPTP mice | Jin et al. 2005 |
| ADAM23 | --- | --- | MPTP mice | Jin et al. 2005 |
| Adapter-related protein complex 2 α1 subunit | --- | --- | --- | --- |
| Adenine phosphoribosyltransferase | Swedish human mutant transgenic rat | Wilson et al. 2005 | --- | --- |
| Adenosine | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Adenosylhomocysteinase at 13 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Adenylosuccinate synthetase | --- | --- | MPTP mice | Jin et al. 2005 |
| Adenyl cyclase-associated protein 1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| ADP-ribosylarigine hydrolase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Alpha adducing | --- | --- | MPTP mice | Jin et al. 2005 |
| Amyloid β A4 protein precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Astrocytic phosphoprotein PEA-15 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Bent | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Chaoptic | --- | --- | A53T Drosphila, A30P Drosophila | Xun et al. 2008, Xun et al. 2007a |
| Cheerio | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Chickadee | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Claudin-11 | --- | --- | MPTP mice | Jin et al. 2005 |
| Cleavage and polyadenylation specificity factor, 100 kDa subunit | --- | --- | MPTP mice | Jin et al. 2005 |
| D-dopachrome tautomerase | --- | --- | MPTP mice | Jin et al. 2005 |
| Diphenol oxidase 2 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Discs large homolog 1 | --- | --- | MPTP mice | Jin et al. 2005 |
| DnaJ homolog subfamily A member 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Failed axon connections | --- | --- | A53T Drosophila | Xun et al. 2008 |
| Fat body protein 1 | --- | --- | A53T Drosophila, A30P Drosophila | Xun et al. 2008, Xun et al. 2007a |
| Fatty acid binding protein | MPTP mice | Diedrich et al. 2008 | ||
| Frizzled 7 precursor | --- | --- | MPTP mice | Jin et al. 2005 |
| Glutactin | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Growth factor receptor bound protein 2 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Guanine nucleotide-binding protein β-subunit 1 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Hemoglobin α | GSKβ | Tilleman et al. 2002 | --- | --- |
| Heparin sulfate N-deacetylase/N-sulfotransferase | --- | --- | MPTP mice | Jin et al. 2005 |
| HLA-B-asssociated transcript 1a | --- | --- | MPTP mice | Jin et al. 2005 |
| Hypothetical serine-rich containing protein | --- | --- | MPTP mice | Jin et al. 2005 |
| Hypoxanthine guanine phosphoribosyl transferase | GSKβ | Tilleman et al. 2002 | --- | --- |
| Karst | --- | --- | A53T Drosophila | Xun et al. 2008 |
| Lactoylglutathione lyase | --- | --- | MPTP mice | Jin et al. 2005 |
| MKIAA0968 protein, splice isoform α | --- | --- | MPTP mice | Jin et al. 2005 |
| Methylcrotonyl-CoA carboxlase β-chain | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Nectin-like protein 1 | --- | --- | MPTP mice | Jin et al. 2005 |
| Nucleoside diphosphate kinase A | GSKβ | Tilleman et al. 2002 | --- | --- |
| Nucleoside diphosphate kinase 2 | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Odorant binding protein 44a | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Odorant binding protein 99 | --- | --- | A53T Drosophila | Xun et al. 2008 |
| Peanut-like protein | GSKβ | Tilleman et al. 2002 | --- | --- |
| Protein CGI-51 homolog | --- | --- | MPTP mice | Jin et al. 2005 |
| Pugilista | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Punch | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Purple | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Q8R3V5 SH3 domain GRB2-like protein B2 | --- | --- | MPTP mice | Jin et al. 2005 |
| Retinal degeneration A | --- | --- | A53T Drosphila | Xun et al. 2008 |
| Retinin | --- | --- | A53T Drosophila, A30P Drosophila | Xun et al. 2008, Xun et al. 2007a |
| Ribose-phosphate pyrophosokinase 1 | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Rpt1 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Serine (or cysteine) proteinase inhibitor, clade A, member 1e | MPTP mice | Diedrich et al. 2008 | ||
| Serum albumin | GSKβ | Tilleman et al. 2002 | parkin KO mice, MPTP mice | Periquet et al. 2005, Diedrich et al. 2008 |
| Similar to CGI-49 | --- | --- | MPTP mice | Jin et al. 2005 |
| Small nuclear ribonucleoprotein polypeptide F | --- | --- | MPTP mice | Diedrich et al. 2008 |
| Spermidine synthase | --- | --- | parkin KO mice | Periquet et al. 2005 |
| Splice isoform 1 of P60202 myelin proteolipid protein | --- | --- | MPTP mice | Jin et al. 2005 |
| Splice isoform 3 of Q9EPR4 solute carrier family 23, member 2 | --- | --- | MPTP mice | Jin et al. 2005 |
| TER94 | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Transformation sensitive protein IEF SSP 3521 | GSKβ | Tilleman et al. 2002 | --- | --- |
| Trehalose-6-phosphate synthase 1b | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Tropomyosin | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Uncharacterized hematopoietic stem/progenitor cells protein MDS029 homolog | --- | --- | MPTP mice | Jin et al. 2005 |
| Walrus | --- | --- | A30P Drosophila | Xun et al. 2007a |
| Valosin-containing protein | --- | --- | MPTP mice | Diedrich et al. 2008 |
a
It should be noted that proteins listed in this table were grouped according to the text and tables found within the corresponding references (including Zabel et al. 2008). Bolded proteins were identified in proteomics studies of both AD and PD models. Refer to references for a complete list of proteins identified in individual studies.