Table 1.
Ki values of Type II binding analogs
| Group | Compd | Structure (para) | Ki +/− SC (μM) | Compd | Structure (meta) | Ki +/− SD (μM) | Compd | Structure (ortho) | Ki +/− SD (μM) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 |  |
9.94 +/− 0.053 | 2 |  |
9.74 +/− 0.031 | 3 |  |
23.61 +/− 6.08 |
| 2 | 4 |  |
3.67+/−0.082 | 5 |  |
24.08+/−1.03 | 6 |  |
76.19 +/− 11.78 |
| 3 | 7 |  |
0.033 +/− 0.002 | 8 |  |
1.15 +/− 0.002 | 9 |  |
10.67 +/− 1.32 |
| 4 | 10 |  |
0.125 +/− 0.014 | 11 |  |
0.152 +/− 0.004 | 12 |  |
>43.5 |
| 5 | 13 |  |
0.10 +/− 0.008 | 14 |  |
4.06 +/− 1.53 | 15 |  |
3.47 +/− 1.40 |
| 6 | 16 |  |
0.011 +/− 0.001 | 17 |  |
8.55 +/− 1.02 | 18 |  |
>20.6 |
| 7 | 19 |  |
0.012 +/− 0.0007 | 20 |  |
1.89 +/− 0.20 | N/Aa | ||
| 8 | 21 |  |
0.009 +/− 0.001 | 22 |  |
>37.85 | N/Aa | ||
| 9 | N/Aa | 23 |  |
1.25 +/− 0.43 | 24 |  |
1.32+/− 0.10 |
a
compounds not available