Figure 4. Pathogen resistance is not linked with lifespan extension in aging mutants.
Other long and short-lived mutants do not have increased or decreased pathogen resistance. Neither clk-1 (A) nor eat-2 (B) were more resistant than N2 (logrank test, p = 0.02 and 0.7 respectively). clk-1(e2519) was not more sensitive than N2 as replicate experiments yield mean times to death from 92% to 104% relative to N2 (Supplemental Table S1). Likewise, neither jnk-1(gk7) (C) nor jkk-1(km2) (D) was more sensitive than N2 (logrank, p = 0.91 and 0.71 respectively). All experiments used cdc-25.1 RNAi Glp animals. Representative experiments shown. Complete supporting data are presented in Supplementary Table S1.