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. Author manuscript; available in PMC: 2009 May 21.
Published in final edited form as: Mol Cell. 2008 Nov 21;32(4):491–502. doi: 10.1016/j.molcel.2008.10.016

Figure 6. Ezh2 and Eed are required for mesoendodermal (ME) differentiation.

Figure 6

(A) Heat map showing impaired activation of known mesodermal markers in Ezh2−/− and Eed−/−cells as compared to wild-type (WT) cells.

(B) RT-qPCR analysis of T expression along ES cell differentiation by LIF withdrawal.

(C–D) GSEA profiles of ME-high (panel I) and ES-high (panel II) genes by comparing day-6 differentiated Eed−/− (C) or Ezh2−/− (D) cells to wild-type cells.

(E) Heat map of ME-high genes in wild-type and mutant ES cells.

(F) RT-qPCR analysis of pluripotency markers along ES cell differentiation.