Table 2.
Physiological parameters of dSACs
| Physiological parameters | GL-dSAC mean ± SD | EPL-dSAC mean ± SD | GCL-dSAC mean ± SD | ANOVA |
|---|---|---|---|---|
| Spontaneous firing activity (Hz) | 7.41 ± 6.54# | 0.25 ± 1.31#,† | 3.26 ± 3.29† | ** |
| Input resistance (MΩ) | 306.2 ± 150.1# | 160.8 ± 68.6#,† | 406.6 ± 180.7† | ** |
| Membrane time constant (ms) | 25.4 ± 8.9# | 13.5 ± 5.7#,† | 32.8 ± 18.6† | ** |
| Threshold of first AP (mV) | −38.2 ± 5.4 | −39.8 ± 5.6# | −35.1 ± 3.2# | * |
| Peak amplitude of first AP (mV) | 59.9 ± 12.0 | 62.1 ± 15.3 | 54.0 ± 8.3 | ns |
| FWHM of first AP (ms) | 0.52 ± 0.13 | 0.53 ± 0.11 | 0.56 ± 0.12 | ns |
| Amplitude of AHP of first AP (mV) | 14.0 ± 5.1# | 11.2 ± 3.5# | 13.1 ± 2.2 | * |
| Decay time at 75% of AHP amplitude of first AP (ms) | 21.1 ± 19.8# | 25.5 ± 6.3#,† | 12.4 ± 7.5† | ** |
| Ratio of thresholds of last and first AP | 0.86 ± 0.07#,† | 0.73 ± 0.47# | 0.74 ± 0.14† | ** |
| Ratio of peak amplitude of last and first AP | 0.85 ± 0.10 | 0.82 ± 0.07 | 0.74 ± 0.23 | ns |
| Ratio of FWHMs of last and first AP | 1.19 ± 0.17# | 1.26 ± 0.16# | 1.44 ± 0.72 | * |
| Ratio of AHP amplitude of last and first AP | 1.17 ± 0.37# | 1.32 ± 0.23#,† | 1.08 ± 0.12† | ** |
| Ratio of last and first ISI | 1.84 ± 0.92 | 1.87 ± 2.84 | 1.64 ± 0.61 | ns |
| Mean of ISI distribution (ms) | 36.4 ± 19.1# | 40.1 ± 8.8† | 21.1 ± 7.8#,† | ** |
AP, Action potential; AHP, spike afterhyperpolarization; FWHM, full-width at half-maximum amplitude; ISI, interspike interval; ns, not significant.
*p < 0.05, **p < 0.01 (significant differences using Kruskal–Wallis nonparametric ANOVA); #,†p < 0.05 [significant difference using post hoc test (multiple comparisons of mean ranks) between the indicated pairs].