Table 1. Hydrodynamic studies of sLDLR variants.
sLDLR Sample | pH | Concentration (mg/mL) | Sedimentation Coefficient (S20,w) | Axial Ratio (a/b) |
---|---|---|---|---|
Wild Type | 7 | 0.41 | 5.3 | 3.9 |
Wild Type | 5 | 0.36 | 6.1 | 1.3 |
H562K / H586K | 7 | 0.11 | 5.5 | 3.0 |
H562K / H586K | 5 | 0.23 | 5.4 | 3.5 |
H190 K / H562K / H586K | 7 | 0.50 | 5.2 | 4.0 |
H190 K / H562K / H586K | 5 | 0.25 | 5.1 | 4.3 |